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Table of Contents: May 2009

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In the editorial for the May issue the PLoS Medicine editors discuss how clinical research could help to promote better sexual health for all. From the growing burden of sexually transmitted infections to the unmet contraceptive needs of specific groups, sexual health problems are complex, as they sit at the intersection of health, culture, religion, and politics. The editorial draws particular attention to unmet contraceptive needs and unsafe sex, which both figure in the top 20 risk factors for mortality and burden of disease and have been included in PLoS Medicine's recently announced priority areas for publication. Key PLoS Medicine papers that highlight some of the varied themes in sexual health are also highlighted. The editorial concludes that "It is time to realign research and policy making to promote better sexual health for all."

The PLoS Medicine Debate

Do Electronic Health Records Help or Hinder Medical Education?

Jonathan U. Peled, Oren Sagher, Jay B. Morrow, Alison E. Dobbie

Essays

No More Free Drug Samples?

Susan Chimonas, Jerome P. Kassirer

Surgical Task Shifting in Sub-Saharan Africa

Kathryn Chu, Peter Rosseel, Pierre Gielis, Nathan Ford

Preventing Bias in Cluster Randomised Trials

Bruno Giraudeau, Philippe Ravaud

Perspectives

Policy Forum

Guidelines and Guidance

Evaluation and Recommendations on Good Clinical Laboratory Practice Guidelines for Phase I–III Clinical Trials

Marcella Sarzotti-Kelsoe, Josephine Cox, Naana Cleland, Thomas Denny, John Hural, Leila Needham, Daniel Ozaki, Isaac R. Rodriguez-Chavez, Gwynneth Stevens, Timothy Stiles, Tony Tarragona-Fiol, Anita Simkins

Research Articles

Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study

Radek Bukowski, Fergal D. Malone, Flint T. Porter, David A. Nyberg, Christine H. Comstock, Gary D. V. Hankins, Keith Eddleman, Susan J. Gross, Lorraine Dugoff, Sabrina D. Craigo, Ilan E. Timor-Tritsch, Stephen R. Carr, Honor M. Wolfe, Mary E. D'Alton

Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study

Zitta B. Harboe, Reimar W. Thomsen, Anders Riis, Palle Valentiner-Branth, Jens Jørgen Christensen, Lotte Lambertsen, Karen A. Krogfelt, Helle B. Konradsen, Thomas L. Benfield

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

Kittipong Maneechotesuwan, Xin Yao, Kazuhiro Ito, Elen Jazrawi, Omar S. Usmani, Ian M. Adcock, Peter J. Barnes

DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer

Steven T. Lott, Nanyue Chen, Dawn S. Chandler, Qifeng Yang, Luo Wang, Marivonne Rodriguez, Hongyan Xie, Seetharaman Balasenthil, Thomas A. Buchholz, Aysegul A. Sahin, Katrina Chaung, Baili Zhang, Shodimu-Emmanu Olufemi, Jinyun Chen, Henry Adams, Vimla Band, Adel K. El-Naggar, Marsha L. Frazier, Khandan Keyomarsi, Kelly K. Hunt, Subrata Sen, Bruce Haffty, Stephen M. Hewitt, Ralf Krahe, Ann McNeill Killary

Functional Substitution by TAT-Utrophin in Dystrophin-Deficient Mice

Kevin J. Sonnemann, Hanke Heun-Johnson, Amy J. Turner, Kristen A. Baltgalvis, Dawn A. Lowe, James M. Ervasti