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Table of Contents: January 2008

COVER

Healthy Behaviours: Making Lifestyle Changes.

Image Credit: Image by Umberto Salvagnin (http://www.flickr.com/photos/kaibara/)
Issue Image

A study in this month's issue aims to quantify the combined impact of four key healthy behaviors on mortality in men and women in the United Kingdom: not smoking; not being physically inactive; drinking alcohol moderately; and, as represented by our image, having a blood vitamin C level consistent with a fruit and vegetable intake of five servings a day (Khaw, et al. e12). The estimated impact of 14 additional years of life as a result of these behaviors suggests that modest and achievable lifestyle changes can have a marked effect on the health of populations. However, as this month's editorial discusses with reference to previous PLoS Medicine papers on urban safety and physical activity in the United States (Bennett, et al. e306) and food insecurity and high-risk sexual behaviour in Botswana (Weiser, et al. e260), individuals in isolation often cannot make the lifestyle changes they want, and a set of complex processes govern the translation of research into public health outcomes.

Editorial

The PLoS Medicine Debate

Neglected Diseases

Plague: Past, Present, and Future

Nils Chr Stenseth, Bakyt B Atshabar, Mike Begon, Steven R Belmain, Eric Bertherat, Elisabeth Carniel, Kenneth L Gage, Herwig Leirs, Lila Rahalison

Perspectives

Policy Forums

Research in Translation

Student Forum

Research Articles

CONSORT for Reporting Randomized Controlled Trials in Journal and Conference Abstracts: Explanation and Elaboration

Sally Hopewell, Mike Clarke, David Moher, Elizabeth Wager, Philippa Middleton, Douglas G Altman, Kenneth F Schulz , and the CONSORT Group

Multi-Host Transmission Dynamics of Schistosoma japonicum in Samar Province, the Philippines

Steven Riley, Hélène Carabin, Patrick Bélisle, Lawrence Joseph, Veronica Tallo, Ernesto Balolong, A. Lee Willingham III, Tomas J Fernandez Jr., Ryan O'Neal Gonzales, Remigio Olveda, Stephen T McGarvey

Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

Paul W Denton, Jacob D Estes, Zhifeng Sun, Florence A Othieno, Bangdong L Wei, Anja K Wege, Daniel A Powell, Deborah Payne, Ashley T Haase, J. Victor Garcia

Enhancing Exposure of HIV-1 Neutralization Epitopes through Mutations in gp41

Catherine A Blish, Minh-An Nguyen, Julie Overbaugh

Key Role for Clumping Factor B in Staphylococcus aureus Nasal Colonization of Humans

Heiman F. L Wertheim, Evelyn Walsh, Roos Choudhurry, Damian C Melles, Hélène A. M Boelens, Helen Miajlovic, Henri A Verbrugh, Timothy Foster, Alex van Belkum

A Prevalent Variant in PPP1R3A Impairs Glycogen Synthesis and Reduces Muscle Glycogen Content in Humans and Mice

David B Savage, Lanmin Zhai, Balasubramanian Ravikumar, Cheol Soo Choi, Johanna E Snaar, Amanda C McGuire, Sung-Eun Wou, Gemma Medina-Gomez, Sheene Kim, Cheryl B Bock, Dyann M Segvich, Antonio Vidal-Puig, Nicholas J Wareham, Gerald I Shulman, Fredrik Karpe, Roy Taylor, Bartholomew A Pederson, Peter J Roach, Stephen O'Rahilly, Anna A DePaoli-Roach

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

Tim F Cloughesy, Koji Yoshimoto, Phioanh Nghiemphu, Kevin Brown, Julie Dang, Shaojun Zhu, Teli Hsueh, Yinan Chen, Wei Wang, David Youngkin, Linda Liau, Neil Martin, Don Becker, Marvin Bergsneider, Albert Lai, Richard Green, Tom Oglesby, Michael Koleto, Jeff Trent, Steve Horvath, Paul S Mischel, Ingo K Mellinghoff, Charles L Sawyers

IFN-γ Mediates the Rejection of Haematopoietic Stem Cells in IFN-γR1-Deficient Hosts

Martin Rottman, Claire Soudais, Guillaume Vogt, Laurent Renia, Jean-François Emile, Hélène Decaluwe, Jean-Louis Gaillard, Jean-Laurent Casanova

Corrections

Correction: Understanding the Slow Depletion of Memory CD4+ T Cells in HIV Infection

Andrew Yates, Jaroslav Stark, Nigel Klein, Rustom Antia, Robin Callard

Correction: Health Is Still Social: Contemporary Examples in the Age of the Genome

Timothy H Holtz, Seth M Holmes, Scott Stonington, Leon Eisenberg