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Table of Contents: December 2006

COVER

Mutant Palladin Protein in Pancreatic Cancer.

Image Credit: Cover design by Natalie Davis, Public Library of Science, with images taken from Pogue-Geile et al.
Issue Image

A germline mutation in the palladin gene associated with familial pancreatic cancer causes abnormal distribution of the cytoskeletal palladin protein in transfected cells, as shown here. The research article by Pogue-Geile et al. reports the identification of the mutation in a large kindred with pancreatic cancer, as well as the findings that palladin is overexpressed in sporadic pancreatic cancers and that cells expressing the mutant protein have an increased ability to migrate.

Editorial

Essays

Do We Need a World Health Insurance to Realise the Right to Health?

Gorik Ooms, Katharine Derderian, David Melody

Intensive Insulin Therapy in Intensive Care: An Example of the Struggle to Implement Evidence-Based Medicine

Marcus J Schultz, Annick A. N. M Royakkers, Marcel Levi, Hazra S Moeniralam, Peter E Spronk

Perspectives

Mining Methylation for Early Detection of Common Cancers

Romulo M Brena, Christoph Plass, Joseph F Costello

Health in Action

Healthy Penis: San Francisco's Social Marketing Campaign to Increase Syphilis Testing among Gay and Bisexual Men

Katherine Ahrens, Charlotte K Kent, Jorge A Montoya, Harlan Rotblatt, Jacque McCright, Peter Kerndt, Jeffrey D Klausner

Learning Forums

Ophthalmoplegia and Slurred Speech in an Intravenous Drug User

Jaime Vera, Anke Hensiek, Charles Woodrow, Francesca Crawley, Sanjeev Krishna

Hypogammaglobulinemia with Facial Edema

Adina Kay Knight, Lloyd Mayer, Andrew G Franks Jr., Charlotte Cunningham-Rundles

Research Articles

Palladin Mutation Causes Familial Pancreatic Cancer and Suggests a New Cancer Mechanism

Kay L Pogue-Geile, Ru Chen, Mary P Bronner, Tatjana Crnogorac-Jurcevic, Kara White Moyes, Sally Dowen, Carol A Otey, David A Crispin, Ryan D George, David C Whitcomb, Teresa A Brentnall

A Gene Expression Signature Predicts Survival of Patients with Stage I Non-Small Cell Lung Cancer

Yan Lu, William Lemon, Peng-Yuan Liu, Yijun Yi, Carl Morrison, Ping Yang, Zhifu Sun, Janos Szoke, William L Gerald, Mark Watson, Ramaswamy Govindan, Ming You

A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies

David S Shames, Luc Girard, Boning Gao, Mitsuo Sato, Cheryl M Lewis, Narayan Shivapurkar, Aixiang Jiang, Charles M Perou, Young H Kim, Jonathan R Pollack, Kwun M Fong, Chi-Leung Lam, Maria Wong, Yu Shyr, Rita Nanda, Olufunmilayo I Olopade, William Gerald, David M Euhus, Jerry W Shay, Adi F Gazdar, John D Minna

Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain

Jeffrey C Lee, Igor Vivanco, Rameen Beroukhim, Julie H. Y Huang, Whei L Feng, Ralph M DeBiasi, Koji Yoshimoto, Jennifer C King, Phioanh Nghiemphu, Yuki Yuza, Qing Xu, Heidi Greulich, Roman K Thomas, J. Guillermo Paez, Timothy C Peck, David J Linhart, Karen A Glatt, Gad Getz, Robert Onofrio, Liuda Ziaugra, Ross L Levine, Stacey Gabriel, Tomohiro Kawaguchi, Keith O'Neill, Haumith Khan, Linda M Liau, Stanley F Nelson, P. Nagesh Rao, Paul Mischel, Russell O Pieper, Tim Cloughesy, Daniel J Leahy, William R Sellers, Charles L Sawyers, Matthew Meyerson, Ingo K Mellinghoff

Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus

Jason W Bauer, Emily C Baechler, Michelle Petri, Franak M Batliwalla, Dianna Crawford, Ward A Ortmann, Karl J Espe, Wentian Li, Dhavalkumar D Patel, Peter K Gregersen, Timothy W Behrens

Selective Involvement of the Amygdala in Systemic Lupus Erythematosus

Bart J Emmer, Jeroen van der Grond, Gerda M Steup-Beekman, Tom W. J Huizinga, Mark A van Buchem

Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism

Gürkan Kaya, Christian Tran, Olivier Sorg, Raymonde Hotz, Denise Grand, Pierre Carraux, Liliane Didierjean, Ivan Stamenkovic, Jean-Hilaire Saurat

Angiotensin-Converting Enzyme I/D Polymorphism and Preeclampsia Risk: Evidence of Small-Study Bias

Norma C Serrano, Luis A Díaz, Maria C Páez, Clara M Mesa, Rodrigo Cifuentes, Alvaro Monterrosa, Adriana González, Liam Smeeth, Aroon D Hingorani, Juan P Casas

Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity

Bastiaan T Heijmans, Marian Beekman, Jeanine J Houwing-Duistermaat, Mark R Cobain, Jonathan Powell, Gerard Jan Blauw, Frans van der Ouderaa, Rudi G. J Westendorp, P. Eline Slagboom

Impaired Hepatitis C Virus-Specific T Cell Responses and Recurrent Hepatitis C Virus in HIV Coinfection

Arthur Y Kim, Julian Schulze zur Wiesch, Thomas Kuntzen, Joerg Timm, Daniel E Kaufmann, Jared E Duncan, Andrea M Jones, Alysse G Wurcel, Benjamin T Davis, Rajesh T Gandhi, Gregory K Robbins, Todd M Allen, Raymond T Chung, Georg M Lauer, Bruce D Walker

Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection

Saurabh Mehandru, Michael A Poles, Klara Tenner-Racz, Patrick Jean-Pierre, Victoria Manuelli, Peter Lopez, Anita Shet, Andrea Low, Hiroshi Mohri, Daniel Boden, Paul Racz, Martin Markowitz

Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

Damon Deming, Timothy Sheahan, Mark Heise, Boyd Yount, Nancy Davis, Amy Sims, Mehul Suthar, Jack Harkema, Alan Whitmore, Raymond Pickles, Ande West, Eric Donaldson, Kristopher Curtis, Robert Johnston, Ralph Baric

A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages

Maëlle Carraz, Akino Jossang, Jean-François Franetich, Anthony Siau, Liliane Ciceron, Laurent Hannoun, Robert Sauerwein, François Frappier, Philippe Rasoanaivo, Georges Snounou, Dominique Mazier

Erythrocyte G Protein as a Novel Target for Malarial Chemotherapy

Sean C Murphy, Travis Harrison, Heidi E Hamm, Jon W Lomasney, Narla Mohandas, Kasturi Haldar

Prevalence and Causes of Blindness and Low Vision in Southern Sudan

Jeremiah Ngondi, Francis Ole-Sempele, Alice Onsarigo, Ibrahim Matende, Samson Baba, Mark Reacher, Fiona Matthews, Carol Brayne, Paul M Emerson

Blinding Trachoma in Postconflict Southern Sudan

Jeremiah Ngondi, Francis Ole-Sempele, Alice Onsarigo, Ibrahim Matende, Samson Baba, Mark Reacher, Fiona Matthews, Carol Brayne, Paul Emerson

Children with Severe Malnutrition: Can Those at Highest Risk of Death Be Identified with the WHO Protocol?

Kathryn Maitland, James A Berkley, Mohammed Shebbe, Norbert Peshu, Michael English, Charles R. J. C Newton

Impact of Extended-Duration Shifts on Medical Errors, Adverse Events, and Attentional Failures

Laura K Barger, Najib T Ayas, Brian E Cade, John W Cronin, Bernard Rosner, Frank E Speizer, Charles A Czeisler

TV Viewing and Physical Activity Are Independently Associated with Metabolic Risk in Children: The European Youth Heart Study

Ulf Ekelund, Søren Brage, Karsten Froberg, Maarike Harro, Sigmund A Anderssen, Luis B Sardinha, Chris Riddoch, Lars Bo Andersen

Correspondence

HIV-1 Viral Load Assays for Resource-Limited Settings: Clades Matter

Wolfgang Preiser, Jan Felix Drexler, Christian Drosten

Enrolling Adolescents in Research on HIV: Young Women Must Be Included

Alana de Kock, Stephanie Skoler, Khatija Ahmed, Sumen Govender

Corrections

Correction: Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection

Saurabh Mehandru, Michael A Poles, Klara Tenner-Racz, Patrick Jean-Pierre, Victoria Manuelli, Peter Lopez, Anita Shet, Andrea Low, Hiroshi Mohri, Daniel Boden, Paul Racz, Martin Markowitz

Correction: Eight Americas: Investigating Mortality Disparities across Races, Counties, and Race-Counties in the United States

Christopher J. L Murray, Sandeep C Kulkarni, Catherine Michaud, Niels Tomijima, Maria T Bulzacchelli, Terrell J Iandiorio, Majid Ezzati