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Table of Contents: July 2013

COVER

Translating Translational Research into Global Health Gains

Image Credit: School of Natural Resources at Flickr
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In their July editorial, the PLOS Medicine Editors discuss the potential of translational medicine to improve global health and how adherence to reporting standards and guidelines for translational research will lead to better-quality studies in this field.

Two recent translational medicine papers published in PLOS Medicine demonstrate how clinical care can be improved through translational research. The first paper, from Pierre Laurent-Puig and colleagues, reported on a novel transcriptome-based classification of colon cancer that groups colon cancers into six molecular subtypes with prognostic importance. Nathan Ledeboer and colleagues evaluated a diagnostic platform for rapidly detecting Gram-positive bacteria in blood cultures, which could improve decision-making when initiating patient treatment. The editors also argue that advances in translational medicine can lead to improvements in global health, but the technologies must be accessible to low-income countries.

Editorial

Essays

Combatting Substandard and Falsified Medicines: A View from Rwanda

Agnes Binagwaho, Roger Bate, Michel Gasana, Corine Karema, Yves Mucyo, John Patrick Mwesigye, Floribert Biziyaremye, Cameron T. Nutt, Claire M. Wagner, Paul Jensen, Amir Attaran

Reflections on the Global Burden of Disease 2010 Estimates

Peter Byass, Maximilian de Courten, Wendy J. Graham, Lucie Laflamme, Affette McCaw-Binns, Osman A. Sankoh, Stephen M. Tollman, Basia Zaba

Policy Forums

A Comparison of Frameworks Evaluating Evidence for Global Health Interventions

Jill Luoto, Margaret A. Maglione, Breanne Johnsen, Christine Chang, Elizabeth S. Higgs, Tanja Perry, Paul G. Shekelle

Recent Shifts in Global Governance: Implications for the Response to Non-communicable Diseases

Devi Sridhar, Claire E. Brolan, Shireen Durrani, Jennifer Edge, Lawrence O. Gostin, Peter Hill, Martin McKee

Research Articles

Multiplex Identification of Gram-Positive Bacteria and Resistance Determinants Directly from Positive Blood Culture Broths: Evaluation of an Automated Microarray-Based Nucleic Acid Test

Blake W. Buchan, Christine C. Ginocchio, Ryhana Manii, Robert Cavagnolo, Preeti Pancholi, Lettie Swyers, Richard B. Thomson Jr, Christopher Anderson, Karen Kaul, Nathan A. Ledeboer

Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study

Silvia Stringhini, G. David Batty, Pascal Bovet, Martin J. Shipley, Michael G. Marmot, Meena Kumari, Adam G. Tabak, Mika Kivimäki

Changes in Association between Previous Therapeutic Abortion and Preterm Birth in Scotland, 1980 to 2008: A Historical Cohort Study

Clare Oliver-Williams, Michael Fleming, Kirsten Monteath, Angela M. Wood, Gordon C. S. Smith

Factors Affecting the Delivery, Access, and Use of Interventions to Prevent Malaria in Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Jenny Hill, Jenna Hoyt, Anna Maria van Eijk, Lauren D'Mello-Guyett, Feiko O. ter Kuile, Rick Steketee, Helen Smith, Jayne Webster

The Influence of Health Systems on Hypertension Awareness, Treatment, and Control: A Systematic Literature Review

Will Maimaris, Jared Paty, Pablo Perel, Helena Legido-Quigley, Dina Balabanova, Robby Nieuwlaat, Martin Mckee

Risk Prediction for Breast, Endometrial, and Ovarian Cancer in White Women Aged 50 y or Older: Derivation and Validation from Population-Based Cohort Studies

Ruth M. Pfeiffer, Yikyung Park, Aimée R. Kreimer, James V. Lacey Jr, David Pee, Robert T. Greenlee, Saundra S. Buys, Albert Hollenbeck, Bernard Rosner, Mitchell H. Gail, Patricia Hartge