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Research Article

Global Burden of Sickle Cell Anaemia in Children under Five, 2010–2050: Modelling Based on Demographics, Excess Mortality, and Interventions

  • Frédéric B. Piel mail,

    fred.piel@zoo.ox.ac.uk

    Affiliations: Evolutionary Ecology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, United Kingdom, Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom, Global Network for Sickle Cell Disease, Toronto, Ontario, Canada

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  • Simon I. Hay,

    Affiliation: Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Sunetra Gupta,

    Affiliation: Evolutionary Ecology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • David J. Weatherall,

    Affiliation: Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

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  • Thomas N. Williams

    Affiliations: Global Network for Sickle Cell Disease, Toronto, Ontario, Canada, Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research-Coast, Kilifi District Hospital, Kilifi, Kenya, Department of Medicine, Imperial College, St Mary's Hospital, London, United Kingdom

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  • Published: July 16, 2013
  • DOI: 10.1371/journal.pmed.1001484
  • Featured in PLOS Collections

About the Authors

Frédéric B. Piel, Sunetra Gupta
Evolutionary Ecology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, United Kingdom
Frédéric B. Piel, Simon I. Hay
Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom
Frédéric B. Piel, Thomas N. Williams
Global Network for Sickle Cell Disease, Toronto, Ontario, Canada
David J. Weatherall
Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
Thomas N. Williams
Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research-Coast, Kilifi District Hospital, Kilifi, Kenya
Thomas N. Williams
Department of Medicine, Imperial College, St Mary's Hospital, London, United Kingdom

Corresponding Author

Email: fred.piel@zoo.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FBP. Performed the experiments: FBP. Analyzed the data: FBP TNW. Wrote the first draft of the manuscript: FBP. Contributed to the writing of the manuscript: FBP SIH SG DJW TNW. ICMJE criteria for authorship read and met: FBP SIH SG DJW TNW. Agree with manuscript results and conclusions: FBP SIH SG DJW TNW.