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Research Article

Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing

  • Dan Xu,

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Toshi Nishimura,

    Affiliations: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America, Central Institute for Experimental Animals, Kawasaki, Japan, Center for the Advancement of Health and Biosciences, Sunnyvale, California, United States of America

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  • Sachiko Nishimura,

    Affiliation: Center for the Advancement of Health and Biosciences, Sunnyvale, California, United States of America

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  • Haili Zhang,

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Ming Zheng,

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Ying-Ying Guo,

    Affiliation: Department of Drug Disposition, Eli Lilly and Company, Indianapolis, Indiana, United States of America

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  • Marylin Masek,

    Affiliations: Department of Medicine, Stanford University School of Medicine, Stanford California, United States of America, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford California, United States of America, Department of Pathology, Stanford University School of Medicine, Stanford California, United States of America

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  • Sara A. Michie,

    Affiliations: Department of Medicine, Stanford University School of Medicine, Stanford California, United States of America, Department of Pathology, Stanford University School of Medicine, Stanford California, United States of America

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  • Jeffrey Glenn mail,

    jeffrey.glenn@stanford.edu (JG); gpeltz@stanford.edu (GP)

    Affiliations: Department of Medicine, Stanford University School of Medicine, Stanford California, United States of America, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford California, United States of America

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  • Gary Peltz mail

    jeffrey.glenn@stanford.edu (JG); gpeltz@stanford.edu (GP)

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: April 15, 2014
  • DOI: 10.1371/journal.pmed.1001628

About the Authors

Dan Xu, Toshi Nishimura, Haili Zhang, Ming Zheng, Gary Peltz
Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America
Toshi Nishimura
Central Institute for Experimental Animals, Kawasaki, Japan
Toshi Nishimura, Sachiko Nishimura
Center for the Advancement of Health and Biosciences, Sunnyvale, California, United States of America
Ying-Ying Guo
Department of Drug Disposition, Eli Lilly and Company, Indianapolis, Indiana, United States of America
Marylin Masek, Sara A. Michie, Jeffrey Glenn
Department of Medicine, Stanford University School of Medicine, Stanford California, United States of America
Marylin Masek, Jeffrey Glenn
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford California, United States of America
Marylin Masek, Sara A. Michie
Department of Pathology, Stanford University School of Medicine, Stanford California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GP JG YYG. Performed the experiments: DX TN SN HZ MM SM. Analyzed the data: MZ. Contributed reagents/materials/analysis tools: YYG. Wrote the first draft of the manuscript: GP. Contributed to the writing of the manuscript: GP JG SM YYG. ICMJE criteria for authorship read and met: DX TN SN HZ MZ YYG MM SM JG GP. Agree with manuscript results and conclusions: DX TN SN HZ MZ YYG MM SM JG GP.