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Research Article

Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development

  • Allison Jones equal contributor,

    equal contributor Contributed equally to this work with: Allison Jones, Andrew E. Teschendorff, Quanxi Li

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Andrew E. Teschendorff equal contributor,

    equal contributor Contributed equally to this work with: Allison Jones, Andrew E. Teschendorff, Quanxi Li

    Affiliations: Statistical Cancer Genomics, UCL Cancer Institute, University College London, London, United Kingdom, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, Shanghai, China

    X
  • Quanxi Li equal contributor,

    equal contributor Contributed equally to this work with: Allison Jones, Andrew E. Teschendorff, Quanxi Li

    Affiliation: Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Jane D. Hayward,

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Athilakshmi Kannan,

    Affiliation: Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Tim Mould,

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

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  • James West,

    Affiliations: Statistical Cancer Genomics, UCL Cancer Institute, University College London, London, United Kingdom, Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom

    X
  • Michal Zikan,

    Affiliation: Gynaecologic Oncology Center, Department of Obstetrics and Gynaecology, First Faculty of Medicine and General University Hospital, Charles University Prague, Prague, Czech Republic

    X
  • David Cibula,

    Affiliation: Gynaecologic Oncology Center, Department of Obstetrics and Gynaecology, First Faculty of Medicine and General University Hospital, Charles University Prague, Prague, Czech Republic

    X
  • Heidi Fiegl,

    Affiliation: Department of Gynaecology and Obstetrics, Innsbruck Medical University, Innsbruck, Austria

    X
  • Shih-Han Lee,

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Elisabeth Wik,

    Affiliations: Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway, Center for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway

    X
  • Richard Hadwin,

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Rupali Arora,

    Affiliation: Department of Pathology, UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Charlotte Lemech,

    Affiliation: Department of Medical Oncology, UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Henna Turunen,

    Affiliation: Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland

    X
  • Päivi Pakarinen,

    Affiliation: Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland

    X
  • Ian J. Jacobs,

    Affiliations: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom

    X
  • Helga B. Salvesen,

    Affiliations: Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway, Center for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway

    X
  • Milan K. Bagchi,

    Affiliation: Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Indrani C. Bagchi,

    Affiliation: Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Martin Widschwendter mail

    M.Widschwendter@ucl.ac.uk

    Affiliation: Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

    X
  • Published: November 12, 2013
  • DOI: 10.1371/journal.pmed.1001551

About the Authors

Allison Jones, Jane D. Hayward, Tim Mould, Shih-Han Lee, Richard Hadwin, Ian J. Jacobs, Martin Widschwendter
Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom
Andrew E. Teschendorff, James West
Statistical Cancer Genomics, UCL Cancer Institute, University College London, London, United Kingdom
Andrew E. Teschendorff
CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, Shanghai, China
Milan K. Bagchi
Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Quanxi Li, Athilakshmi Kannan, Indrani C. Bagchi
Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
James West
Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom
Michal Zikan, David Cibula
Gynaecologic Oncology Center, Department of Obstetrics and Gynaecology, First Faculty of Medicine and General University Hospital, Charles University Prague, Prague, Czech Republic
Heidi Fiegl
Department of Gynaecology and Obstetrics, Innsbruck Medical University, Innsbruck, Austria
Elisabeth Wik, Helga B. Salvesen
Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway
Elisabeth Wik, Helga B. Salvesen
Center for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
Rupali Arora
Department of Pathology, UCL Cancer Institute, University College London, London, United Kingdom
Charlotte Lemech
Department of Medical Oncology, UCL Cancer Institute, University College London, London, United Kingdom
Henna Turunen, Päivi Pakarinen
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
Ian J. Jacobs
Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom

Corresponding Author

Email: M.Widschwendter@ucl.ac.uk

Competing Interests

IJJ declares that he has competing consultant/advisory roles as follows: Compensated: Abcodia, Becton Dickinson; stock ownership: Abcodia; research funding: Becton Dickinson; patents/licenses/royalties: ROCA Algorithm for Ovarian Cancer Screening. All other authors declare that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MW MKB ICB. Performed the experiments: QL AK AJ SHL HF. Analyzed the data: AET JW RA. Contributed reagents/materials/analysis tools: EW HS HF CL DC MZ HT PP TM RH JH IJJ. Wrote the first draft of the manuscript: MW. Contributed to the writing of the manuscript: AJ AET MKB ICB. ICMJE criteria for authorship read and met: MW AET JW MKB ICB QL AK AJ SHL EW HS HF CL DC MZ HT PP TM RH JH IJJ RA. Agree with manuscript results and conclusions: MW AET JW MKB ICB QL AK AJ SHL EW HS HF CL DC MZ HT PP TM RH JH IJJ RA. Enrolled patients: EW HS HF CL DC MZ HT PP TM RH JH. Designed the software used in analysis: AET JW.