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Research Article

Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection

  • Asuncion Mejias mail,

    Asuncion.Mejias@nationwidechildrens.org (AM); Octavio.Ramilo@nationwidechildrens.org (OR)

    Affiliations: Division of Pediatric Infectious Disease, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America, Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America

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  • Blerta Dimo,

    Affiliation: Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America

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  • Nicolas M. Suarez,

    Affiliation: Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America

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  • Carla Garcia,

    Affiliation: Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • M. Carmen Suarez-Arrabal,

    Affiliation: Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America

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  • Tuomas Jartti,

    Affiliation: Department of Pediatrics, Turku University Hospital, Turku, Finland

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  • Derek Blankenship,

    Affiliation: Department of Statistics, Baylor Research Institute, Dallas, Texas, United States of America

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  • Alejandro Jordan-Villegas,

    Affiliation: Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Monica I. Ardura,

    Affiliation: Division of Pediatric Infectious Disease, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America

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  • Zhaohui Xu,

    Affiliation: Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, United States of America

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  • Jacques Banchereau,

    Affiliation: Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, United States of America

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  • Damien Chaussabel,

    Affiliations: Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, United States of America, Benaroya Research Institute, Seattle, Washington, United States of America

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  • Octavio Ramilo mail

    Asuncion.Mejias@nationwidechildrens.org (AM); Octavio.Ramilo@nationwidechildrens.org (OR)

    Affiliations: Division of Pediatric Infectious Disease, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America, Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America

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  • Published: November 12, 2013
  • DOI: 10.1371/journal.pmed.1001549

About the Authors

Asuncion Mejias, Monica I. Ardura, Octavio Ramilo
Division of Pediatric Infectious Disease, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America
Asuncion Mejias, Blerta Dimo, Nicolas M. Suarez, M. Carmen Suarez-Arrabal, Octavio Ramilo
Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America
Carla Garcia, Alejandro Jordan-Villegas
Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Tuomas Jartti
Department of Pediatrics, Turku University Hospital, Turku, Finland
Derek Blankenship
Department of Statistics, Baylor Research Institute, Dallas, Texas, United States of America
Zhaohui Xu, Jacques Banchereau, Damien Chaussabel
Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, United States of America
Damien Chaussabel
Benaroya Research Institute, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

In the last 3 years, OR has had financial relations with companies that are involved with respiratory viruses research or product as follows: Advisory boards: Gilead, Abbvie, Alios, Quidel; Honoraria for Lectures and Co-Chair Medical Conferences: Abbvie; Cover part of travel expenses to present clinical study at a scientific conference: MedImmune; Research Grant: Abbott Molecular. In the last 3 years, AM has had relations with companies that are involved with respiratory viruses research or product as follows: Advisory Boards: Alios, Janssen Infectious Diseases BVBA; Honoraria for Lectures at CME Conferences: Abbvie; Research Grant: Gilead. All other authors have declared that no competing interest exist.

Author Contributions

Conceived and designed the experiments: AM OR. Performed the experiments: BD NMS ZX AM. Analyzed the data: BD CG AJV MIA NMS DB MCSA AM. Contributed reagents/materials/analysis tools: ZX DC JB. Wrote the first draft of the manuscript: AM BD OR. Contributed to the writing of the manuscript: AM OR BD JB DC. ICMJE criteria for authorship read and met: AM BD NMS CG MCSA TJ DB AJV MIA ZX JB DC OR. Agree with manuscript results and conclusions: AM BD NMS CG MCSA TJ DB AJV MIA ZX JB DC OR. Enrolled patients: CG MCSA AJV MIA AM TJ.