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Research Article

Carriage of Mycoplasma pneumoniae in the Upper Respiratory Tract of Symptomatic and Asymptomatic Children: An Observational Study

  • Emiel B. M. Spuesens mail,

    e.spuesens@erasmusmc.nl

    Affiliations: Department of Paediatric Infectious Diseases and Immunology, Erasmus MC–Sophia, Rotterdam, The Netherlands, Laboratory of Paediatrics, Erasmus MC–Sophia, Rotterdam, The Netherlands

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  • Pieter L. A. Fraaij,

    Affiliations: Department of General Paediatrics, Erasmus MC–Sophia, Rotterdam, The Netherlands, Department of Virology, Erasmus MC, Rotterdam, The Netherlands

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  • Eline G. Visser,

    Affiliation: Department of Paediatric Infectious Diseases and Immunology, Erasmus MC–Sophia, Rotterdam, The Netherlands

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  • Theo Hoogenboezem,

    Affiliation: Laboratory of Paediatrics, Erasmus MC–Sophia, Rotterdam, The Netherlands

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  • Wim C. J. Hop,

    Affiliation: Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands

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  • Léon N. A. van Adrichem,

    Affiliation: Department of Plastic Surgery, Erasmus MC, Rotterdam, The Netherlands

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  • Frank Weber,

    Affiliation: Department of Anaesthesiology, Erasmus MC, Rotterdam, The Netherlands

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  • Henriette A. Moll,

    Affiliation: Department of General Paediatrics, Erasmus MC–Sophia, Rotterdam, The Netherlands

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  • Berth Broekman,

    Affiliation: General Practitioners Cooperative, Rotterdam, The Netherlands

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  • Marjolein Y. Berger,

    Affiliation: Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Tineke van Rijsoort-Vos,

    Affiliation: Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands

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  • Alex van Belkum,

    Affiliations: Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands, Microbiology R&D, bioMérieux, La Balme-les-Grottes, France

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  • Martin Schutten,

    Affiliation: Department of Virology, Erasmus MC, Rotterdam, The Netherlands

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  • Suzan D. Pas,

    Affiliation: Department of Virology, Erasmus MC, Rotterdam, The Netherlands

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  • Albert D. M. E. Osterhaus,

    Affiliation: Department of Virology, Erasmus MC, Rotterdam, The Netherlands

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  • Nico G. Hartwig,

    Affiliation: Department of Paediatric Infectious Diseases and Immunology, Erasmus MC–Sophia, Rotterdam, The Netherlands

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  • Cornelis Vink,

    Affiliation: Laboratory of Paediatrics, Erasmus MC–Sophia, Rotterdam, The Netherlands

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  • Annemarie M. C. van Rossum

    Affiliation: Department of Paediatric Infectious Diseases and Immunology, Erasmus MC–Sophia, Rotterdam, The Netherlands

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  • Published: May 14, 2013
  • DOI: 10.1371/journal.pmed.1001444
  • Featured in PLOS Collections

About the Authors

Emiel B. M. Spuesens, Eline G. Visser, Nico G. Hartwig, Annemarie M. C. van Rossum
Department of Paediatric Infectious Diseases and Immunology, Erasmus MC–Sophia, Rotterdam, The Netherlands
Emiel B. M. Spuesens, Theo Hoogenboezem, Cornelis Vink
Laboratory of Paediatrics, Erasmus MC–Sophia, Rotterdam, The Netherlands
Pieter L. A. Fraaij, Henriette A. Moll
Department of General Paediatrics, Erasmus MC–Sophia, Rotterdam, The Netherlands
Pieter L. A. Fraaij, Martin Schutten, Suzan D. Pas, Albert D. M. E. Osterhaus
Department of Virology, Erasmus MC, Rotterdam, The Netherlands
Wim C. J. Hop
Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands
Léon N. A. van Adrichem
Department of Plastic Surgery, Erasmus MC, Rotterdam, The Netherlands
Frank Weber
Department of Anaesthesiology, Erasmus MC, Rotterdam, The Netherlands
Berth Broekman
General Practitioners Cooperative, Rotterdam, The Netherlands
Marjolein Y. Berger
Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Tineke van Rijsoort-Vos, Alex van Belkum
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
Alex van Belkum
Microbiology R&D, bioMérieux, La Balme-les-Grottes, France

Corresponding Author

Email: e.spuesens@erasmusmc.nl

Competing Interests

At the time of the study, AB was a paid member on the Cepheid Scientific Advisory Board in which he is no longer taking part. After the study, AB joined bioMérieux, a company specializing in infectious disease' diagnostics. ADO is Head of the department of Virology of the Erasmus MC. He is involved in or with many initiatives within the virology field. This involvement ranges from expert advice to various international organisations involved in the area of general human and veterinary health to advising spin-out companies of the Erasmus University Medical Center Rotterdam that are endeavouring to bridge the gap between scientific discovery/knowledge and putting these to practical use in society. For purposes of transparency and to avoid of possible conflicts of interest, Professor Osterhaus discloses all his interests in matters related, directly or indirectly, to his position as head of the Department of Virology of Erasmus MC. Professor Osterhaus has share certificates in Viroclinics Biosciences B.V. AMR received fees for speaking from Abbott. AMR has received grants from the NutsOhra Foundation, The Netherlands, and the Thrasher Fund, USA. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EBS PLF NGH CV AMR. Performed the experiments: EBS TH TRV MS SDP CV. Analyzed the data: EBS PF WCH AB MS ADO NGH CV AMR. Contributed reagents/materials/analysis tools: LNA FW AB MS ADO CV. Wrote the first draft of the manuscript: EBS CV AMR. Contributed to the writing of the manuscript: EBS PLF WCH HAM MYB AB MS ADO NGH CV AMR. ICMJE criteria for authorship read and met: EBS PLF EGV TH WCH LNA FW HAM BB MYB TR AB MS SDP ADO NGH CV AMR. Agree with manuscript results and conclusions: EBS PLF EGV TH WCH LNA FW HAM BB MYB TR AB MS SDP ADO NGH CV AMR. Facilitated data collection: LNA FW HAM BB MYB.