Advertisement
Research Article

Prophylactic Perioperative Sodium Bicarbonate to Prevent Acute Kidney Injury Following Open Heart Surgery: A Multicenter Double-Blinded Randomized Controlled Trial

  • Michael Haase equal contributor,

    equal contributor Contributed equally to this work with: Michael Haase, Anja Haase-Fielitz

    Affiliation: Department of Nephrology and Hypertension, Diabetes, and Endocrinology, Otto-von-Guericke-University Magdeburg, Germany

    X
  • Anja Haase-Fielitz equal contributor mail,

    equal contributor Contributed equally to this work with: Michael Haase, Anja Haase-Fielitz

    anja.haase-fielitz@med.ovgu.de (AHF); Rinaldo.Bellomo@austin.org.au (RB)

    Affiliation: Department of Nephrology and Hypertension, Diabetes, and Endocrinology, Otto-von-Guericke-University Magdeburg, Germany

    X
  • Michael Plass,

    Affiliation: Department of Anesthesiology, The German Heart Center, Berlin, Germany

    X
  • Hermann Kuppe,

    Affiliation: Department of Anesthesiology, The German Heart Center, Berlin, Germany

    X
  • Roland Hetzer,

    Affiliation: Department of Cardiothoracic Surgery, The German Heart Center, Berlin, Germany

    X
  • Claire Hannon,

    Affiliation: Nephrology and Clinical Pharmacology, University College Dublin School of Medicine and Medical Science, Dublin, Ireland

    X
  • Patrick T. Murray,

    Affiliation: Nephrology and Clinical Pharmacology, University College Dublin School of Medicine and Medical Science, Dublin, Ireland

    X
  • Michael J. Bailey,

    Affiliation: The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia

    X
  • Rinaldo Bellomo mail,

    anja.haase-fielitz@med.ovgu.de (AHF); Rinaldo.Bellomo@austin.org.au (RB)

    Affiliation: Department of Intensive Care, The Austin Hospital, Melbourne, Australia

    X
  • Sean M. Bagshaw

    Affiliation: Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada

    X
  • Published: April 16, 2013
  • DOI: 10.1371/journal.pmed.1001426

About the Authors

Michael Haase, Anja Haase-Fielitz
Department of Nephrology and Hypertension, Diabetes, and Endocrinology, Otto-von-Guericke-University Magdeburg, Germany
Michael Plass, Hermann Kuppe
Department of Anesthesiology, The German Heart Center, Berlin, Germany
Roland Hetzer
Department of Cardiothoracic Surgery, The German Heart Center, Berlin, Germany
Claire Hannon, Patrick T. Murray
Nephrology and Clinical Pharmacology, University College Dublin School of Medicine and Medical Science, Dublin, Ireland
Michael J. Bailey
The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Rinaldo Bellomo
Department of Intensive Care, The Austin Hospital, Melbourne, Australia
Sean M. Bagshaw
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada

Corresponding Authors

Competing Interests

MH and RB hold a patent on the use of sodium bicarbonate infusions to prevent acute kidney injury. MH, SMB, and PM received lecture fees from companies (incl. Abbott Diagnostics, Alere) involved in the development of neutrophil gelatinase-associated lipocalin as renal biomarker. The authors declare no other competing interests.

Author Contributions

Conceived and designed the experiments: MH AHF RB. Performed the experiments: MH AHF RB PM SMB. Analyzed the data: MJB AHF. Contributed reagents/materials/analysis tools: MH AHF RB. Wrote the first draft of the manuscript: MH AHF. Contributed to the writing of the manuscript: MP HK RH CH PM MJB RB SMB. ICMJE criteria for authorship read and met: MH AHF RB MP HK RH CH PM MJB SMB. Agree with manuscript results and conclusions: MH AHF RB MP HK RH CH PM MJB SMB. Enrolled patients: MH AHF RB SMB PM.