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Research Article

Adjunctive Atypical Antipsychotic Treatment for Major Depressive Disorder: A Meta-Analysis of Depression, Quality of Life, and Safety Outcomes

  • Glen I. Spielmans mail,

    glen.spielmans@metrostate.edu

    Affiliation: Department of Psychology, Metropolitan State University, St. Paul, Minnesota, United States of America

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  • Margit I. Berman,

    Affiliation: Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire, United States of America

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  • Eftihia Linardatos,

    Affiliation: Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire, United States of America

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  • Nicholas Z. Rosenlicht,

    Affiliations: Department of Psychiatry, University of California at San Francisco, San Francisco, California, United States of America, San Francisco Veterans Affairs Medical Center, San Francisco, California, United States of America

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  • Angela Perry,

    Affiliation: Department of Psychology, Metropolitan State University, St. Paul, Minnesota, United States of America

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  • Alexander C. Tsai

    Affiliations: Center for Global Health, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Psychiatry, Chester M. Pierce, MD Division of Global Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: March 12, 2013
  • DOI: 10.1371/journal.pmed.1001403
  • Featured in PLOS Collections

About the Authors

Glen I. Spielmans, Angela Perry
Department of Psychology, Metropolitan State University, St. Paul, Minnesota, United States of America
Margit I. Berman, Eftihia Linardatos
Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
Nicholas Z. Rosenlicht
Department of Psychiatry, University of California at San Francisco, San Francisco, California, United States of America
Nicholas Z. Rosenlicht
San Francisco Veterans Affairs Medical Center, San Francisco, California, United States of America
Alexander C. Tsai
Center for Global Health, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Alexander C. Tsai
Department of Psychiatry, Chester M. Pierce, MD Division of Global Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Alexander C. Tsai
Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: glen.spielmans@metrostate.edu

Competing Interests

GIS is a member of Healthy Skepticism and holds shares of less than $10,000 in a mutual fund (Vanguard Health Care) that invests heavily in pharmaceutical firms. NZR is a member of both the National Physicians Alliance and Healthy Skepticism. NZR is also a local site investigator on a Department of Veterans Affairs sponsored multi-site trial of treatments for resistant depression. One study arm is receiving aripiprazole augmentation. The study is receiving no funding from pharmaceutical companies. NZR is also serving as a consultant in a lawsuit against the manufacturer of aripiprazole. ACT acknowledges salary support through Mentored Patient-Oriented Research Career Development Award K23 MH-096620, US National Institute of Mental Health. ACT is a former board member of the ethics committee, and former member, of the National Physicians Alliance. GIS had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. No specific funding was provided to support the conduct of this meta-analysis. The authors declare no other competing interests.

Author Contributions

Conceived and designed the experiments: GIS MIB ACT NZR ACT EL. Performed the experiments: EL GIS AP MIB. Analyzed the data: GIS. Wrote the first draft of the manuscript: GIS. Contributed to the writing of the manuscript: ACT MIB NZR EL AP. ICMJE criteria for authorship read and met: GIS MIB EL NZR AP ACT. Agree with manuscript results and conclusions: GIS MIB EL NZR AP ACT.