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Research Article

Personalized Prediction of Lifetime Benefits with Statin Therapy for Asymptomatic Individuals: A Modeling Study

  • Bart S. Ferket,

    Affiliations: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands, Department of Radiology, Erasmus MC, Rotterdam, the Netherlands

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  • Bob J. H. van Kempen,

    Affiliations: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands, Department of Radiology, Erasmus MC, Rotterdam, the Netherlands

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  • Jan Heeringa,

    Affiliation: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands

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  • Sandra Spronk,

    Affiliations: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands, Department of Radiology, Erasmus MC, Rotterdam, the Netherlands

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  • Kirsten E. Fleischmann,

    Affiliation: Department of Medicine, University of California, San Francisco, California, United States of America

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  • Rogier L. G. Nijhuis,

    Affiliation: Department of Cardiology, Ziekenhuisgroep Twente, Hengelo, the Netherlands

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  • Albert Hofman,

    Affiliation: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands

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  • Ewout W. Steyerberg,

    Affiliation: Department of Public Health, Erasmus MC, Rotterdam, the Netherlands

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  • M. G. Myriam Hunink mail

    m.hunink@erasmusmc.nl

    Affiliations: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands, Department of Radiology, Erasmus MC, Rotterdam, the Netherlands, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.pmed.1001361

About the Authors

Bart S. Ferket, Bob J. H. van Kempen, Jan Heeringa, Sandra Spronk, Albert Hofman, M. G. Myriam Hunink
Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands
Bart S. Ferket, Bob J. H. van Kempen, Sandra Spronk, M. G. Myriam Hunink
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Kirsten E. Fleischmann
Department of Medicine, University of California, San Francisco, California, United States of America
Rogier L. G. Nijhuis
Department of Cardiology, Ziekenhuisgroep Twente, Hengelo, the Netherlands
Ewout W. Steyerberg
Department of Public Health, Erasmus MC, Rotterdam, the Netherlands
M. G. Myriam Hunink
Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts, United States of America

Corresponding Author

Email: m.hunink@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MH BF BvK. Performed the experiments: BF BvK. Analyzed the data: BF BvK MH ES. Wrote the first draft of the manuscript: BF. Contributed to the writing of the manuscript: BvK JH SS KF RN AH ES MH. ICMJE criteria for authorship read and met: BF BvK JH SS KF RN AH ES MH. Agree with manuscript results and conclusions: BF BvK JH SS KF RN AH ES MH.