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Research Article

Population Health Impact and Cost-Effectiveness of Tuberculosis Diagnosis with Xpert MTB/RIF: A Dynamic Simulation and Economic Evaluation

  • Nicolas A. Menzies mail,

    nmenzies@fas.harvard.edu

    Affiliations: Center for Health Decision Sciences, Harvard School of Public Health, Boston, Massachusetts, United States of America, Institute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Ted Cohen,

    Affiliations: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Hsien-Ho Lin,

    Affiliation: Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan

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  • Megan Murray,

    Affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Joshua A. Salomon

    Affiliations: Center for Health Decision Sciences, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Global Health and Population, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Published: November 20, 2012
  • DOI: 10.1371/journal.pmed.1001347

About the Authors

Nicolas A. Menzies, Joshua A. Salomon
Center for Health Decision Sciences, Harvard School of Public Health, Boston, Massachusetts, United States of America
Nicolas A. Menzies
Institute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Ted Cohen, Megan Murray
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Ted Cohen
Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Hsien-Ho Lin
Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
Joshua A. Salomon
Department of Global Health and Population, Harvard School of Public Health, Boston, Massachusetts, United States of America

Corresponding Author

Email: nmenzies@fas.harvard.edu

Competing Interests

JAS and MM are members of the PLOS Medicine editorial board. The authors declare that no other competing interests exist.

Author Contributions

Analyzed the data: NAM. Wrote the first draft of the manuscript: NAM. Contributed to the writing of the manuscript: TC HHL MM JAS. ICMJE criteria for authorship read and met: NAM TC HHL MM JAS. Agree with manuscript results and conclusions: NAM TC HHL MM JAS. Conceived and designed the study: NAM TC MM JAS. Contributed to model design and parameterization: NAM TC HHL MM JAS.