Advertisement
Research Article

Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

  • Peter Recknagel equal contributor,

    equal contributor Contributed equally to this work with: Peter Recknagel, Falk A. Gonnert

    Affiliations: Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany, Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, United Kingdom

    X
  • Falk A. Gonnert equal contributor,

    equal contributor Contributed equally to this work with: Peter Recknagel, Falk A. Gonnert

    Affiliation: Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

    X
  • Martin Westermann,

    Affiliation: Electron Microscopy Center, Jena University Hospital, Jena, Germany

    X
  • Sandro Lambeck,

    Affiliation: Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

    X
  • Amelie Lupp,

    Affiliation: Department of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany

    X
  • Alain Rudiger,

    Affiliation: Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, United Kingdom

    X
  • Alex Dyson,

    Affiliation: Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, United Kingdom

    X
  • Jane E. Carré,

    Affiliation: Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, United Kingdom

    X
  • Andreas Kortgen,

    Affiliation: Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

    X
  • Christoph Krafft,

    Affiliation: Institute of Photonic Technology, Jena, Germany

    X
  • Jürgen Popp,

    Affiliation: Institute of Photonic Technology, Jena, Germany

    X
  • Christoph Sponholz,

    Affiliation: Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

    X
  • Valentin Fuhrmann,

    Affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

    X
  • Ingrid Hilger,

    Affiliation: Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany

    X
  • Ralf A. Claus,

    Affiliation: Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

    X
  • Niels C. Riedemann,

    Affiliation: Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

    X
  • Reinhard Wetzker,

    Affiliation: Department of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany

    X
  • Mervyn Singer,

    Affiliation: Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, United Kingdom

    X
  • Michael Trauner ,

    Affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

    These authors are joint senior authors on this work.

    X
  • Michael Bauer mail

    Michael.Bauer@med.uni-jena.de

    Affiliation: Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

    These authors are joint senior authors on this work.

    X
  • Published: November 13, 2012
  • DOI: 10.1371/journal.pmed.1001338

About the Authors

Peter Recknagel, Falk A. Gonnert, Sandro Lambeck, Andreas Kortgen, Christoph Sponholz, Ralf A. Claus, Niels C. Riedemann, Michael Bauer
Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany
Peter Recknagel, Alain Rudiger, Alex Dyson, Jane E. Carré, Mervyn Singer
Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, United Kingdom
Martin Westermann
Electron Microscopy Center, Jena University Hospital, Jena, Germany
Amelie Lupp
Department of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany
Christoph Krafft, Jürgen Popp
Institute of Photonic Technology, Jena, Germany
Valentin Fuhrmann, Michael Trauner
Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Ingrid Hilger
Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany
Reinhard Wetzker
Department of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany

Corresponding Author

Email: Michael.Bauer@med.uni-jena.de

Competing Interests

The authors declare that a patent has been filed regarding the use of bile acids for the diagnosis of sepsis (MB). MS is a member of the Editorial Board of PLOS Medicine. The authors declare that no other competing interests exist.

Author Contributions

Conceived and designed the experiments: PR FAG AK JP IH RAC NCR RW MS MT MB. Performed the experiments: PR FAG MW AL AR AD JEC CK CS VF. Analyzed the data: PR FAG MW SL CK. Contributed reagents/materials/analysis tools: SL CK JP IH MT RW. Wrote the first draft of the manuscript: PR FAG MS MT MB. Contributed to the writing of the manuscript: PR FAG RW MS MT MB. ICMJE criteria for authorship read and met: PR FAG MW SL AL AR AD JEC AK CK JP CS VF IH RAC NCR RW MS MT MB. Agree with manuscript results and conclusions: PR FAG MW SL AL AR AD JEC AK CK JP CS VF IH RAC NCR RW MS MT MB.