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Research Article

Effect of Statins on Venous Thromboembolic Events: A Meta-analysis of Published and Unpublished Evidence from Randomised Controlled Trials

  • Kazem Rahimi mail,

    kazem.rahimi@georgecentre.ox.ac.uk

    Affiliations: George Centre for Healthcare Innovation, University of Oxford, Oxford, United Kingdom, Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Hospitals NHS Trust, Department of Cardiology, Oxford, United Kingdom

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  • Neeraj Bhala,

    Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom

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  • Pieter Kamphuisen,

    Affiliation: Department of Vascular Medicine, University Medical Center Groningen, Groningen, The Netherlands

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  • Jonathan Emberson,

    Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom

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  • Sara Biere-Rafi,

    Affiliation: Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands

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  • Vera Krane,

    Affiliation: Department of Internal Medicine, Division of Nephrology, University of Würzburg, Würzburg, Germany

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  • Michele Robertson,

    Affiliation: Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland

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  • John Wikstrand,

    Affiliation: Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

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  • John McMurray

    Affiliation: British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Published: September 18, 2012
  • DOI: 10.1371/journal.pmed.1001310

About the Authors

Kazem Rahimi
George Centre for Healthcare Innovation, University of Oxford, Oxford, United Kingdom
Kazem Rahimi
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Kazem Rahimi
Oxford University Hospitals NHS Trust, Department of Cardiology, Oxford, United Kingdom
Neeraj Bhala, Jonathan Emberson
Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom
Pieter Kamphuisen
Department of Vascular Medicine, University Medical Center Groningen, Groningen, The Netherlands
Sara Biere-Rafi
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
Vera Krane
Department of Internal Medicine, Division of Nephrology, University of Würzburg, Würzburg, Germany
Michele Robertson
Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland
John Wikstrand
Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
John McMurray
British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

Corresponding Author

Email: kazem.rahimi@georgecentre.ox.ac.uk

Competing Interests

VK is a member of the steering committee of the SHARP trial (Study of Heart and Renal Protection), and was involved in the 4D Study (German Diabetes and Dialysis Study) as clinical coordinator. MR is a member of the PLOS Medicine Editorial Board. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KR NB PK. Analyzed the data: KR JE. Contributed reagents/materials/analysis tools: KR NB PK JE SB VK MR JW JM. Wrote the first draft of the manuscript: KR. Contributed to the writing of the manuscript: KR NB PK JE SB VK JW JM. ICMJE criteria for authorship read and met: KR NB PK JE SB VK MR JW JM. Agree with manuscript results and conclusions: KR NB PK JE SB VK MR JW JM.