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Research Article

Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case-Control Study

  • Anna Rosanas-Urgell equal contributor,

    equal contributor Contributed equally to this work with: Anna Rosanas-Urgell, Enmoore Lin

    Affiliation: PNG Institute of Medical Research, Madang, Papua New Guinea

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  • Enmoore Lin equal contributor,

    equal contributor Contributed equally to this work with: Anna Rosanas-Urgell, Enmoore Lin

    Affiliation: PNG Institute of Medical Research, Madang, Papua New Guinea

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  • Laurens Manning,

    Affiliation: Department of Medicine & Pharmacology, University of Western Australia, Perth, Australia

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  • Patricia Rarau,

    Affiliation: PNG Institute of Medical Research, Madang, Papua New Guinea

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  • Moses Laman,

    Affiliation: PNG Institute of Medical Research, Madang, Papua New Guinea

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  • Nicolas Senn,

    Affiliations: PNG Institute of Medical Research, Madang, Papua New Guinea, Swiss Tropical & Public Health Institute, Basel, Switzerland

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  • Brian T. Grimberg,

    Affiliation: Center of Global Health & Diseases (CGHD), Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Livingstone Tavul,

    Affiliation: PNG Institute of Medical Research, Madang, Papua New Guinea

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  • Danielle I. Stanisic,

    Affiliations: PNG Institute of Medical Research, Madang, Papua New Guinea, Infection & Immunity Division, Walter+Eliza Hall Institute, Parkville, Victoria, Australia

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  • Leanne J. Robinson,

    Affiliations: PNG Institute of Medical Research, Madang, Papua New Guinea, Infection & Immunity Division, Walter+Eliza Hall Institute, Parkville, Victoria, Australia

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  • John J. Aponte,

    Affiliation: Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain

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  • Elijah Dabod,

    Affiliation: PNG Institute of Medical Research, Madang, Papua New Guinea

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  • John C. Reeder,

    Affiliation: The Burnet Institute, Melbourne, Australia

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  • Peter Siba,

    Affiliation: PNG Institute of Medical Research, Madang, Papua New Guinea

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  • Peter A. Zimmerman,

    Affiliation: Center of Global Health & Diseases (CGHD), Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Timothy M. E. Davis,

    Affiliation: Department of Medicine & Pharmacology, University of Western Australia, Perth, Australia

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  • Christopher L. King,

    Affiliations: Center of Global Health & Diseases (CGHD), Case Western Reserve University, Cleveland, Ohio, United States of America, Veterans Affairs Medical Center, Cleveland, Ohio, United States of America

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  • Pascal Michon,

    Affiliations: PNG Institute of Medical Research, Madang, Papua New Guinea, Faculty of Health Sciences, Divine Word University, Madang, Papua New Guinea

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  • Ivo Mueller mail

    ivomueller@fastmail.fm

    Affiliations: PNG Institute of Medical Research, Madang, Papua New Guinea, Infection & Immunity Division, Walter+Eliza Hall Institute, Parkville, Victoria, Australia, Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain

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  • Published: September 04, 2012
  • DOI: 10.1371/journal.pmed.1001305

About the Authors

Anna Rosanas-Urgell, Enmoore Lin, Patricia Rarau, Moses Laman, Nicolas Senn, Livingstone Tavul, Danielle I. Stanisic, Leanne J. Robinson, Elijah Dabod, Peter Siba, Pascal Michon, Ivo Mueller
PNG Institute of Medical Research, Madang, Papua New Guinea
Laurens Manning, Timothy M. E. Davis
Department of Medicine & Pharmacology, University of Western Australia, Perth, Australia
Nicolas Senn
Swiss Tropical & Public Health Institute, Basel, Switzerland
Brian T. Grimberg, Peter A. Zimmerman, Christopher L. King
Center of Global Health & Diseases (CGHD), Case Western Reserve University, Cleveland, Ohio, United States of America
Danielle I. Stanisic, Leanne J. Robinson, Ivo Mueller
Infection & Immunity Division, Walter+Eliza Hall Institute, Parkville, Victoria, Australia
John J. Aponte, Ivo Mueller
Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain
John C. Reeder
The Burnet Institute, Melbourne, Australia
Christopher L. King
Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
Pascal Michon
Faculty of Health Sciences, Divine Word University, Madang, Papua New Guinea

Corresponding Author

Email: ivomueller@fastmail.fm

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IM PM CLK TMED PAZ PS JCR. Performed the experiments: AR EL LM PR ML NS BTG LT DIS LR ED PM IM. Analyzed the data: JJA IM. Wrote the first draft of the manuscript: IM. Contributed to the writing of the manuscript: AR EL LM NS BTG JJA JCR PS PAZ TMED CLK PM IM. ICMJE criteria for authorship read and met: AR EL LM PR ML NS BTG LT DIS LR JJA ED JCR PS PAZ TMED CLK PM IM. Agree with manuscript results and conclusions: AR EL LM PR ML NS BTG LT DIS LR JJA ED JCR PS PAZ TMED CLK PM IM. Enrolled patients: LM PR ML NS LT DIS LR ED PM IM.