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Research Article

Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement

  • Ilse C. E. Hendriksen,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Juliet Mwanga-Amumpaire,

    Affiliation: Mbarara University of Science and Technology and Epicentre Research Base, Mbarara, Uganda

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  • Lorenz von Seidlein,

    Affiliation: Menzies School of Health Research, Casuarina, NT, Australia

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  • George Mtove,

    Affiliation: National Institute for Medical Research, Amani Centre, Tanga, Tanzania

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  • Lisa J. White,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Rasaq Olaosebikan,

    Affiliation: Medical Research Council Laboratories, Banjul, The Gambia

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  • Sue J. Lee,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Antoinette K. Tshefu,

    Affiliation: Kinshasa School of Public Health, Kingasani Research Centre, Kinshasa, Democratic Republic of the Congo

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  • Charles Woodrow,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Ben Amos,

    Affiliation: Teule Hospital, Muheza, Tanzania

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  • Corine Karema,

    Affiliation: Malaria Control Program, Ministry of Health, Kigali, Rwanda

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  • Somporn Saiwaew,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Kathryn Maitland,

    Affiliation: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Research Programme, Kilifi, Kenya

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  • Ermelinda Gomes,

    Affiliation: Hospital Central da Beira, Beira, Mozambique

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  • Wirichada Pan-Ngum,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Samwel Gesase,

    Affiliation: National Institute for Medical Research, Tanga Medical Research Centre, Tanga, Tanzania

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  • Kamolrat Silamut,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Hugh Reyburn,

    Affiliation: London School of Tropical Medicine & Hygiene, London, United Kingdom

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  • Sarah Joseph,

    Affiliation: Medical Research Council, London, United Kingdom

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  • Kesinee Chotivanich,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Caterina I. Fanello,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Nicholas P. J. Day,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Nicholas J. White,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Arjen M. Dondorp mail

    arjen@tropmedres.ac

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Published: August 21, 2012
  • DOI: 10.1371/journal.pmed.1001297

About the Authors

Ilse C. E. Hendriksen, Lisa J. White, Sue J. Lee, Charles Woodrow, Somporn Saiwaew, Wirichada Pan-Ngum, Kamolrat Silamut, Kesinee Chotivanich, Caterina I. Fanello, Nicholas P. J. Day, Nicholas J. White, Arjen M. Dondorp
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Ilse C. E. Hendriksen, Lisa J. White, Sue J. Lee, Charles Woodrow, Caterina I. Fanello, Nicholas P. J. Day, Nicholas J. White, Arjen M. Dondorp
Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom
Juliet Mwanga-Amumpaire
Mbarara University of Science and Technology and Epicentre Research Base, Mbarara, Uganda
Lorenz von Seidlein
Menzies School of Health Research, Casuarina, NT, Australia
George Mtove
National Institute for Medical Research, Amani Centre, Tanga, Tanzania
Rasaq Olaosebikan
Medical Research Council Laboratories, Banjul, The Gambia
Antoinette K. Tshefu
Kinshasa School of Public Health, Kingasani Research Centre, Kinshasa, Democratic Republic of the Congo
Ben Amos
Teule Hospital, Muheza, Tanzania
Corine Karema
Malaria Control Program, Ministry of Health, Kigali, Rwanda
Kathryn Maitland
Kenya Medical Research Institute (KEMRI)–Wellcome Trust Research Programme, Kilifi, Kenya
Ermelinda Gomes
Hospital Central da Beira, Beira, Mozambique
Samwel Gesase
National Institute for Medical Research, Tanga Medical Research Centre, Tanga, Tanzania
Hugh Reyburn
London School of Tropical Medicine & Hygiene, London, United Kingdom
Sarah Joseph
Medical Research Council, London, United Kingdom

Corresponding Author

Email: arjen@tropmedres.ac

Competing Interests

Lorenz von Seidlein and Nicholas J. White are on the Editorial Board of PLOS Medicine. The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CIF AMD ICEH NPJD LVS NJW. Performed the experiments: SS ICEH CW SJ KS KC BA. Analyzed the data: ICEH LJW SJL CW AMD. Contributed reagents/materials/analysis tools: LJW SJL WPN HR. Wrote the first draft of the manuscript: ICEH. Contributed to the writing of the manuscript: AMD CW LVS HR NPJD NJW. ICMJE criteria for authorship read and met: ICEH JMA LVS GM LJW RO SJL AKT CW BA CK SS KM EG WPN SG KS HR SJ KC CIF NPJD NJW AMD. Agree with manuscript results and conclusions: ICEH JMA LVS GM LJW RO SJL AKT CW BA CK SS KM EG WPN SG KS HR SJ KC CIF NPJD NJW AMD. Enrolled patients: JMA GM SG RO AKT CK KM EG ICEH LVS.