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Research Article

Effects of Intensive Blood Pressure Lowering on Cardiovascular and Renal Outcomes: A Systematic Review and Meta-Analysis

  • Jicheng Lv,

    Affiliations: The George Institute for Global Health, The University of Sydney, Sydney, Australia, Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China

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  • Bruce Neal,

    Affiliation: The George Institute for Global Health, The University of Sydney, Sydney, Australia

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  • Parya Ehteshami,

    Affiliation: The George Institute for Global Health, The University of Sydney, Sydney, Australia

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  • Toshiharu Ninomiya,

    Affiliation: Department of Medicine and Clinical Science Graduate School of Medical Sciences, Kyushu University, Japan

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  • Mark Woodward,

    Affiliations: The George Institute for Global Health, The University of Sydney, Sydney, Australia, Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Anthony Rodgers,

    Affiliation: The George Institute for Global Health, The University of Sydney, Sydney, Australia

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  • Haiyan Wang,

    Affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China

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  • Stephen MacMahon,

    Affiliation: The George Institute for Global Health, The University of Sydney, Sydney, Australia

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  • Fiona Turnbull,

    Affiliation: The George Institute for Global Health, The University of Sydney, Sydney, Australia

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  • Graham Hillis,

    Affiliation: The George Institute for Global Health, The University of Sydney, Sydney, Australia

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  • John Chalmers,

    Affiliation: The George Institute for Global Health, The University of Sydney, Sydney, Australia

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  • Vlado Perkovic mail

    vperkovic@george.org.au

    Affiliation: The George Institute for Global Health, The University of Sydney, Sydney, Australia

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  • Published: August 21, 2012
  • DOI: 10.1371/journal.pmed.1001293

About the Authors

Jicheng Lv, Bruce Neal, Parya Ehteshami, Mark Woodward, Anthony Rodgers, Stephen MacMahon, Fiona Turnbull, Graham Hillis, John Chalmers, Vlado Perkovic
The George Institute for Global Health, The University of Sydney, Sydney, Australia
Jicheng Lv, Haiyan Wang
Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
Mark Woodward
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America
Toshiharu Ninomiya
Department of Medicine and Clinical Science Graduate School of Medical Sciences, Kyushu University, Japan

Corresponding Author

Email: vperkovic@george.org.au

Competing Interests

JL has received grant support from Pfizer for hypertension research. VP, MW, SM, and JC have received honoraria from Servier for scientific presentations relating to blood pressure. SM and JC were principal investigators on ADVANCE, a blood pressure lowering trial funded by Servier and the Australian National Health and Medical Research Council. BN has received BP-related research support from Servier, and honoraria for scientific presentations related to blood pressure from Novartis, Tanabe, and Servier. AR has received an unrestricted grant from Dr Reddy’s Laboratories for a trial that includes blood pressure-lowering agents. PE, FT, TN, HW, and GH declare they have no competing interests.

Author Contributions

Conceived and designed the experiments: JL VP. Performed the experiments: JL PE. Analyzed the data: JL BN PE VP. Wrote the first draft of the manuscript: JL. Contributed to the writing of the manuscript: JL BN PE VP. ICMJE criteria for authorship read and met: JL BN PE TN MW AR HW SM FT GH JC VP. Agree with manuscript results and conclusions: JL BN PE TN MW AR HW SM FT GH JC VP. Contributed to data interpretation and critical revision of the report: TN MW AR HW SM FT GH JC.