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Research Article

Surveillance of Infection Severity: A Registry Study of Laboratory Diagnosed Clostridium difficile

  • Iryna Schlackow,

    Affiliation: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • A. Sarah Walker,

    Affiliations: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, MRC Clinical Trials Unit, London, United Kingdom

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  • Kate Dingle,

    Affiliation: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • David Griffiths,

    Affiliation: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • Sarah Oakley,

    Affiliation: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • John Finney,

    Affiliation: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • Ali Vaughan,

    Affiliation: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • Martin J. Gill,

    Affiliation: University Hospitals Birmingham NHS Foundation Trust, United Kingdom

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  • Derrick W. Crook,

    Affiliation: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • Tim E. A. Peto,

    Affiliation: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • David H. Wyllie mail

    david.wyllie@ndm.ox.ac.uk

    Affiliations: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Health Protection Agency, Oxford, United Kingdom

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  • Published: July 31, 2012
  • DOI: 10.1371/journal.pmed.1001279

About the Authors

Iryna Schlackow, A. Sarah Walker, Kate Dingle, David Griffiths, Sarah Oakley, John Finney, Ali Vaughan, Derrick W. Crook, Tim E. A. Peto, David H. Wyllie
NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
A. Sarah Walker
MRC Clinical Trials Unit, London, United Kingdom
David H. Wyllie
Health Protection Agency, Oxford, United Kingdom
Martin J. Gill
University Hospitals Birmingham NHS Foundation Trust, United Kingdom

Corresponding Author

Email: david.wyllie@ndm.ox.ac.uk

Competing Interests

IS was supported by NIHR grant RP-DG-1108-10125, and DW was supported in part by the Health Protection Agency during the work described. We declare no other financial relationships with any organisations that might have an interest in the submitted work in the previous three years. IS, DW, TP, DC and ASW have applied for a patent related to the techniques described. TP has been a scientific advisor to Optimer Pharmaceuticals.

Author Contributions

Conceived and designed the experiments: DHW ASW. Performed the experiments: DHW ASW IS JF AV DG SO KD MG. Analyzed the data: IS ASW DHW MG. Contributed reagents/materials/analysis tools: JF AV DG SO KD. Wrote the first draft of the manuscript: DHW IS. Contributed to the writing of the manuscript: DHW TP DW IS JF MG DC. ICMJE criteria for authorship read and met: DHW ASW IS AV DG SO KD JF MG TP DC. Agree with manuscript results and conclusions: DHW ASW IS AV DG SO KD JF MG TP DC.