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Research Article

Antiretroviral Therapy for Prevention of Tuberculosis in Adults with HIV: A Systematic Review and Meta-Analysis

  • Amitabh B. Suthar mail,

    amitabh.suthar@gmail.com

    Affiliation: Department of HIV/AIDS, World Health Organization, Geneva, Switzerland

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  • Stephen D. Lawn,

    Affiliations: Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa, Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Julia del Amo,

    Affiliation: National Centre of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain

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  • Haileyesus Getahun,

    Affiliation: Stop TB Department, World Health Organization, Geneva, Switzerland

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  • Christopher Dye,

    Affiliation: HIV/AIDS, Tuberculosis, Malaria and Neglected Tropical Diseases Cluster, World Health Organization, Geneva, Switzerland

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  • Delphine Sculier,

    Affiliation: Stop TB Department, World Health Organization, Geneva, Switzerland

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  • Timothy R. Sterling,

    Affiliation: Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Richard E. Chaisson,

    Affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Brian G. Williams,

    Affiliation: South African Centre for Epidemiological Modelling and Analysis, University of Stellenbosch, Stellenbosch, South Africa

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  • Anthony D. Harries,

    Affiliations: International Union Against Tuberculosis and Lung Disease, Paris, France, Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Reuben M. Granich

    Affiliation: Department of HIV/AIDS, World Health Organization, Geneva, Switzerland

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  • Published: July 24, 2012
  • DOI: 10.1371/journal.pmed.1001270

About the Authors

Amitabh B. Suthar, Reuben M. Granich
Department of HIV/AIDS, World Health Organization, Geneva, Switzerland
Stephen D. Lawn
Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
Stephen D. Lawn
Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom
Julia del Amo
National Centre of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
Haileyesus Getahun, Delphine Sculier
Stop TB Department, World Health Organization, Geneva, Switzerland
Christopher Dye
HIV/AIDS, Tuberculosis, Malaria and Neglected Tropical Diseases Cluster, World Health Organization, Geneva, Switzerland
Timothy R. Sterling
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Richard E. Chaisson
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Brian G. Williams
South African Centre for Epidemiological Modelling and Analysis, University of Stellenbosch, Stellenbosch, South Africa
Anthony D. Harries
International Union Against Tuberculosis and Lung Disease, Paris, France
Anthony D. Harries
Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

Corresponding Author

Email: amitabh.suthar@gmail.com

Competing Interests

TRS received a research grant from Bristol Myers Squibb for HIV observational studies, a research grant from Pfizer for HIV observational studies, and research grant support from the US National Institutes of Health and the US Centers for Disease Control and Prevention. TRS is also a member of a data safety monitoring board for Otsuka. ABS, HG, DS, and RMG work for WHO. The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions or policies of the World Health Organization. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ABS SDL JdA ADH RMG. Performed the experiments: ABS JdA DS RMG. Analyzed the data: ABS BGW. Wrote the first draft of the manuscript: ABS. Contributed to the writing of the manuscript: SDL JdA HG CD DS TRS REC BGW ADH RMG. ICMJE criteria for authorship read and met: ABS SDL JdA HG CD DS TRS REC BGW ADH RMG. Agree with manuscript results and conclusions: ABS SDL JdA HG CD DS TRS REC BGW ADH RMG.