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Research Article

The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach

  • Børge G. Nordestgaard equal contributor mail,

    equal contributor Contributed equally to this work with: Børge G. Nordestgaard, Tom M. Palmer

    Boerge.Nordestgaard@regionh.dk (BGN); n.j.timpson@bris.ac.uk (NJT)

    Affiliations: Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Tom M. Palmer equal contributor,

    equal contributor Contributed equally to this work with: Børge G. Nordestgaard, Tom M. Palmer

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Marianne Benn,

    Affiliations: Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Jeppe Zacho,

    Affiliations: Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Anne Tybjærg-Hansen,

    Affiliations: The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark, The Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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  • George Davey Smith,

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Nicholas J. Timpson mail

    Boerge.Nordestgaard@regionh.dk (BGN); n.j.timpson@bris.ac.uk (NJT)

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Published: May 01, 2012
  • DOI: 10.1371/journal.pmed.1001212

About the Authors

Børge G. Nordestgaard, Marianne Benn, Jeppe Zacho
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
Børge G. Nordestgaard, Marianne Benn, Jeppe Zacho, Anne Tybjærg-Hansen
The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
Børge G. Nordestgaard, Anne Tybjærg-Hansen
The Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark
Børge G. Nordestgaard, Marianne Benn, Jeppe Zacho, Anne Tybjærg-Hansen
Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Tom M. Palmer, George Davey Smith, Nicholas J. Timpson
MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
Tom M. Palmer, George Davey Smith, Nicholas J. Timpson
School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
Anne Tybjærg-Hansen
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Corresponding Authors

Competing Interests

George Davey Smith is on the PLoS Medicine Editorial Board. The authors have declared that no other competing interests exist.

Author Contributions

Conceived and designed the experiments: BGN NJT GDS. Analyzed the data: NJT TMP MB. Wrote the first draft of the manuscript: NJT. Contributed to the writing of the manuscript: NJT TMP BGN GDS JZ ATH MB. ICMJE criteria for authorship read and met: NJT TMP BGN GDS JZ ATH MB. Agree with manuscript results and conclusions: NJT TMP BGN GDS JZ ATH MB. Enrolled patients: BGN JZ ATH.