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Research Article

Induction of Labor versus Expectant Management in Women with Preterm Prelabor Rupture of Membranes between 34 and 37 Weeks: A Randomized Controlled Trial

  • David P. van der Ham mail,

    dpvanderham@gmail.com

    Affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands

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  • Sylvia M. C. Vijgen,

    Affiliation: Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands

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  • Jan G. Nijhuis,

    Affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands

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  • Johannes J. van Beek,

    Affiliation: Department of Obstetrics and Gynecology, VieCuri Medical Center, Venlo, The Netherlands

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  • Brent C. Opmeer,

    Affiliation: Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Amsterdam, The Netherlands

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  • Antonius L. M. Mulder,

    Affiliation: Department of Pediatrics, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands

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  • Rob Moonen,

    Affiliation: Department of Pediatrics, Atrium Medical Center, Heerlen, The Netherlands

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  • Mariët Groenewout,

    Affiliation: Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands

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  • Mariëlle G. van Pampus,

    Affiliation: Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands

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  • Gerald D. Mantel,

    Affiliation: Department of Obstetrics and Gynecology, Isala Klinieken, Zwolle, The Netherlands

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  • Kitty W. M. Bloemenkamp,

    Affiliation: Department of Obstetrics and Gynecology, Leiden University Medical Center, Leiden, The Netherlands

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  • Wim J. van Wijngaarden,

    Affiliation: Department of Obstetrics and Gynecology, Bronovo Hospital, The Hague, The Netherlands

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  • Marko Sikkema,

    Affiliation: Department of Obstetrics and Gynecology, Ziekenhuisgroep Twente, Almelo, The Netherlands

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  • Monique C. Haak,

    Affiliation: Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands

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  • Paula J. M. Pernet,

    Affiliation: Department of Obstetrics and Gynecology, Kennemer Gasthuis, Haarlem, The Netherlands

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  • Martina Porath,

    Affiliation: Department of Obstetrics and Gynecology, Maxima Medical Center, Veldhoven, The Netherlands

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  • Jan F. M. Molkenboer,

    Affiliation: Department of Obstetrics and Gynecology, Sint Anna Hospital, Geldrop, The Netherlands

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  • Simone Kuppens,

    Affiliation: Department of Obstetrics and Gynecology, Catharina Hospital, Eindhoven, The Netherlands

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  • Anneke Kwee,

    Affiliation: Department of Obstetrics and Gynecology, University Medical Center, Utrecht, The Netherlands

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  • Michael E. Kars,

    Affiliation: Department of Obstetrics and Gynecology, Sint Antonius Hospital, Nieuwegein, The Netherlands

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  • Mallory Woiski,

    Affiliation: Department of Obstetrics and Gynecology, Sint Radboud University Medical Center, Nijmegen, The Netherlands

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  • Martin J. N. Weinans,

    Affiliation: Department of Obstetrics and Gynecology, Gelderse Vallei Hospital, Ede, The Netherlands

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  • Hajo I. J. Wildschut,

    Affiliation: Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Bettina M. C. Akerboom,

    Affiliation: Department of Obstetrics and Gynecology, Albert Schweitzer Hospital, Dordrecht, The Netherlands

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  • Ben W. J. Mol,

    Affiliation: Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands

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  • Christine Willekes,

    Affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands

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  • on behalf of the PPROMEXIL trial group

    The PPROMEXIL trial group collaborators are listed in the Acknowledgments.

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  • Published: April 24, 2012
  • DOI: 10.1371/journal.pmed.1001208

About the Authors

David P. van der Ham, Jan G. Nijhuis, Christine Willekes
Department of Obstetrics and Gynecology, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands
Sylvia M. C. Vijgen, Ben W. J. Mol
Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
Johannes J. van Beek
Department of Obstetrics and Gynecology, VieCuri Medical Center, Venlo, The Netherlands
Brent C. Opmeer
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
Antonius L. M. Mulder
Department of Pediatrics, Maastricht University Medical Center, GROW—School for Oncology and Developmental Biology, Maastricht, The Netherlands
Rob Moonen
Department of Pediatrics, Atrium Medical Center, Heerlen, The Netherlands
Mariët Groenewout, Mariëlle G. van Pampus
Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands
Gerald D. Mantel
Department of Obstetrics and Gynecology, Isala Klinieken, Zwolle, The Netherlands
Kitty W. M. Bloemenkamp
Department of Obstetrics and Gynecology, Leiden University Medical Center, Leiden, The Netherlands
Wim J. van Wijngaarden
Department of Obstetrics and Gynecology, Bronovo Hospital, The Hague, The Netherlands
Marko Sikkema
Department of Obstetrics and Gynecology, Ziekenhuisgroep Twente, Almelo, The Netherlands
Monique C. Haak
Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
Paula J. M. Pernet
Department of Obstetrics and Gynecology, Kennemer Gasthuis, Haarlem, The Netherlands
Martina Porath
Department of Obstetrics and Gynecology, Maxima Medical Center, Veldhoven, The Netherlands
Jan F. M. Molkenboer
Department of Obstetrics and Gynecology, Sint Anna Hospital, Geldrop, The Netherlands
Simone Kuppens
Department of Obstetrics and Gynecology, Catharina Hospital, Eindhoven, The Netherlands
Anneke Kwee
Department of Obstetrics and Gynecology, University Medical Center, Utrecht, The Netherlands
Michael E. Kars
Department of Obstetrics and Gynecology, Sint Antonius Hospital, Nieuwegein, The Netherlands
Mallory Woiski
Department of Obstetrics and Gynecology, Sint Radboud University Medical Center, Nijmegen, The Netherlands
Martin J. N. Weinans
Department of Obstetrics and Gynecology, Gelderse Vallei Hospital, Ede, The Netherlands
Hajo I. J. Wildschut
Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands
Bettina M. C. Akerboom
Department of Obstetrics and Gynecology, Albert Schweitzer Hospital, Dordrecht, The Netherlands

Corresponding Author

Email: dpvanderham@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BM CW. Analyzed the data: DH SV BO BM. Wrote the first draft of the manuscript: DH BO BM. Contributed to the writing of the manuscript: DH JN BO JvB AM WvW BM CW. ICMJE criteria for authorship read and met: DH SV JN JvB BO AM RM MG MvP GM KB WvW MS MH PP MP JM SK AK MK MW MJW HW BA BM CW. Agree with manuscript results and conclusions: DH SV JN JvB BO AM RM MG MvP GM KB WvW MS MH PP MP JM SK AK MK MW MJW HW BA BM CW. Enrolled patients: DH JN JvB MG MvP GM KB WvW MS MH PP MP JM SK AK MK MW MJW HW BA BM CW. Scored and discussed neonatal outcome on neonatal sepsis: AM RM. Supported and helped with the database: SV. Obtained funding for the trial: BM CW.