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Research Article

No Treatment versus 24 or 60 Weeks of Antiretroviral Treatment during Primary HIV Infection: The Randomized Primo-SHM Trial

  • Marlous L. Grijsen equal contributor mail,

    equal contributor Contributed equally to this work with: Marlous L. Grijsen, Radjin Steingrover

    m.l.grijsen@amc.uva.nl

    Affiliation: Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Radjin Steingrover equal contributor,

    equal contributor Contributed equally to this work with: Marlous L. Grijsen, Radjin Steingrover

    Affiliations: Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Global Health, Amsterdam Institute for Global Health and Development, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Ferdinand W. N. M. Wit,

    Affiliation: Department of Global Health, Amsterdam Institute for Global Health and Development, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Suzanne Jurriaans,

    Affiliation: Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Annelies Verbon,

    Affiliation: Department of Medical Microbiology, Maastricht University Medical Center, Maastricht, The Netherlands

    Current address: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Kees Brinkman,

    Affiliation: Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands

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  • Marchina E. van der Ende,

    Affiliation: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Robin Soetekouw,

    Affiliation: Department of Internal Medicine, Kennemer Gasthuis, Haarlem, The Netherlands

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  • Frank de Wolf,

    Affiliation: HIV Monitoring Foundation, Amsterdam, The Netherlands

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  • Joep M. A. Lange,

    Affiliation: Department of Global Health, Amsterdam Institute for Global Health and Development, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Hanneke Schuitemaker,

    Affiliation: Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Jan M. Prins,

    Affiliation: Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • on behalf of the Primo-SHM Study Group
  • Published: March 27, 2012
  • DOI: 10.1371/journal.pmed.1001196

About the Authors

Marlous L. Grijsen, Radjin Steingrover, Jan M. Prins
Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Radjin Steingrover, Ferdinand W. N. M. Wit, Joep M. A. Lange
Department of Global Health, Amsterdam Institute for Global Health and Development, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Suzanne Jurriaans
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Annelies Verbon
Department of Medical Microbiology, Maastricht University Medical Center, Maastricht, The Netherlands
Kees Brinkman
Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
Marchina E. van der Ende
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Robin Soetekouw
Department of Internal Medicine, Kennemer Gasthuis, Haarlem, The Netherlands
Frank de Wolf
HIV Monitoring Foundation, Amsterdam, The Netherlands
Hanneke Schuitemaker
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Corresponding Author

Email: m.l.grijsen@amc.uva.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMP JMAL HS. Analyzed the data: MLG FWNMW JMP. Wrote the first draft of the manuscript: MLG JMP. Contributed to the writing of the manuscript: MLG RSt FWMNW SJ AV KB MEE RSo FdW JMAL HS JMP. ICMJE criteria for authorship read and met: MLG RSt FWMNW SJ AV KB MEE RSo FdW JMAL HS JMP. Agree with manuscript results and conclusions: MLG RSt FWMNW SJ AV KB MEE RSo FdW JMAL HS JMP.