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Research Article

Characterisation of Clostridium difficile Hospital Ward–Based Transmission Using Extensive Epidemiological Data and Molecular Typing

  • A. Sarah Walker equal contributor mail,

    equal contributor Contributed equally to this work with: A. Sarah Walker, David W. Eyre

    asw@ctu.mrc.ac.uk

    Affiliations: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Medical Research Council Clinical Trials Unit, London, United Kingdom

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  • David W. Eyre equal contributor,

    equal contributor Contributed equally to this work with: A. Sarah Walker, David W. Eyre

    Affiliation: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • David H. Wyllie,

    Affiliation: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • Kate E. Dingle,

    Affiliations: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Laboratory Sciences, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

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  • Rosalind M. Harding,

    Affiliation: Department of Zoology, Oxford University, Oxford, United Kingdom

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  • Lily O'Connor,

    Affiliation: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • David Griffiths,

    Affiliations: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

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  • Ali Vaughan,

    Affiliations: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

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  • John Finney,

    Affiliation: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

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  • Mark H. Wilcox,

    Affiliations: Department of Microbiology, The General Infirmary, Old Medical School, Leeds, United Kingdom, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom

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  • Derrick W. Crook,

    Affiliations: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

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  • Tim E. A. Peto, on behalf of the Infections in Oxforshire Research Database

    Affiliations: National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

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  • Published: February 07, 2012
  • DOI: 10.1371/journal.pmed.1001172

About the Authors

A. Sarah Walker, David W. Eyre, David H. Wyllie, Kate E. Dingle, Lily O'Connor, David Griffiths, Ali Vaughan, John Finney, Derrick W. Crook, Tim E. A. Peto
National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
A. Sarah Walker
Medical Research Council Clinical Trials Unit, London, United Kingdom
Kate E. Dingle
Nuffield Department of Clinical Laboratory Sciences, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom
Rosalind M. Harding
Department of Zoology, Oxford University, Oxford, United Kingdom
David Griffiths, Ali Vaughan, Derrick W. Crook, Tim E. A. Peto
Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom
Mark H. Wilcox
Department of Microbiology, The General Infirmary, Old Medical School, Leeds, United Kingdom
Mark H. Wilcox
Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom

Corresponding Author

Email: asw@ctu.mrc.ac.uk

Competing Interests

The institution of DWC and TEAP received per-case funding from Optimer Pharmaceuticals to support fidaxomicin trial patient expenses. DWC and TEAP also received honoraria from Optimer Pharmaceuticals for participation in additional meetings related to investigative planning for fidaxomicin. MHW has received honoraria for consultancy work, financial support to attend meetings and research funding from bioMerieux, Optimer, Novacta, Pfizer, Summit, The Medicines Company, and Viropharma. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TEAP ASW DCW DWE MHW RMH. Performed the experiments: DHW LOC KED DG AV JF. Analyzed the data: DWE TEAP ASW. Wrote the first draft of the manuscript: TEAP DWE ASW DWC. Contributed to the writing of the manuscript: ASW DWE DHW KED RMH LOC DG AV JF MHW DCW TEAP. ICMJE criteria for authorship read and met: ASW DWE DHW KED RMH LOC DG AV JF MHW DCW TEAP. Agree with manuscript results and conclusions: ASW DWE DHW KED RMH LOC DG AV JF MHW DCW TEAP.