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Research Article

What Will It Take to Eliminate Pediatric HIV? Reaching WHO Target Rates of Mother-to-Child HIV Transmission in Zimbabwe: A Model-Based Analysis

  • Andrea L. Ciaranello mail,

    aciaranello@partners.org

    Affiliation: Division of Infectious Disease, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Freddy Perez,

    Affiliations: INSERM U897 Africa Team of the Institut de Santé Publique, d'Epidémiologie et de Développement, Université Bordeaux Segalen, Bordeaux, France, HIV/AIDS Unit, Pan American Health Organization, Washington, District of Columbia, United States of America

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  • Jo Keatinge,

    Affiliation: Zimbabwe Country Office, Elizabeth Glaser Pediatric AIDS Foundation, Harare, Zimbabwe

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  • Ji-Eun Park,

    Affiliation: Division of General Medicine, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Barbara Engelsmann,

    Affiliation: Organization of Public Health Interventions and Development, Harare, Zimbabwe

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  • Matthews Maruva,

    Affiliation: Zimbabwe Country Office, Elizabeth Glaser Pediatric AIDS Foundation, Harare, Zimbabwe

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  • Rochelle P. Walensky,

    Affiliations: Division of Infectious Disease, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Infectious Disease, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard University Center for AIDS Research, Boston, Massachusetts, United States of America

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  • Francois Dabis,

    Affiliation: INSERM U897 Africa Team of the Institut de Santé Publique, d'Epidémiologie et de Développement, Université Bordeaux Segalen, Bordeaux, France

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  • Jennifer Chu,

    Affiliation: Division of General Medicine, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Asinath Rusibamayila,

    Affiliation: Division of General Medicine, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Angela Mushavi,

    Affiliation: Ministry of Health and Child Welfare, Harare, Zimbabwe

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  • Kenneth A. Freedberg

    Affiliations: Division of Infectious Disease, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of General Medicine, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts, United States of America, Harvard University Center for AIDS Research, Boston, Massachusetts, United States of America

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  • Published: January 10, 2012
  • DOI: 10.1371/journal.pmed.1001156

About the Authors

Andrea L. Ciaranello, Rochelle P. Walensky, Kenneth A. Freedberg
Division of Infectious Disease, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Freddy Perez, Francois Dabis
INSERM U897 Africa Team of the Institut de Santé Publique, d'Epidémiologie et de Développement, Université Bordeaux Segalen, Bordeaux, France
Freddy Perez
HIV/AIDS Unit, Pan American Health Organization, Washington, District of Columbia, United States of America
Jo Keatinge, Matthews Maruva
Zimbabwe Country Office, Elizabeth Glaser Pediatric AIDS Foundation, Harare, Zimbabwe
Ji-Eun Park, Jennifer Chu, Asinath Rusibamayila, Kenneth A. Freedberg
Division of General Medicine, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Barbara Engelsmann
Organization of Public Health Interventions and Development, Harare, Zimbabwe
Rochelle P. Walensky
Division of Infectious Disease, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Angela Mushavi
Ministry of Health and Child Welfare, Harare, Zimbabwe
Kenneth A. Freedberg
Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts, United States of America
Rochelle P. Walensky, Kenneth A. Freedberg
Harvard University Center for AIDS Research, Boston, Massachusetts, United States of America

Corresponding Author

Email: aciaranello@partners.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AC FP JK BE MM RW FD AM KF. Performed the experiments: AC JP JE AR. Contributed reagents/materials/analysis tools: AC RW KF. Wrote the first draft of the manuscript: AC. Contributed to the writing of the manuscript: AC FP JK JP BE MM RW FD JC AR AM KF. ICMJE criteria for authorship read and met: AC FP JK JP BE MM RW FD JC AR AM KF. Agree with manuscript results and conclusions: AC FP JK JP BE MM RW FD JC AR AM KF. Critical interpretation of model results: AC FP JK JP BE MM RW FD JC AR AM KF.