Advertisement
Research Article

Effect of Supplementation with Zinc and Other Micronutrients on Malaria in Tanzanian Children: A Randomised Trial

  • Jacobien Veenemans,

    Affiliations: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands, Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands

    X
  • Paul Milligan,

    Affiliation: Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom

    X
  • Andrew M. Prentice,

    Affiliations: MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom, MRC Keneba, The Gambia

    X
  • Laura R. A. Schouten,

    Affiliation: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands

    X
  • Nienke Inja,

    Affiliation: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands

    X
  • Aafke C. van der Heijden,

    Affiliation: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands

    X
  • Linsey C. C. de Boer,

    Affiliation: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands

    X
  • Esther J. S. Jansen,

    Affiliation: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands

    X
  • Anna E. Koopmans,

    Affiliation: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands

    X
  • Wendy T. M. Enthoven,

    Affiliation: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands

    X
  • Rob J. Kraaijenhagen,

    Affiliation: Meander Medical Centre, Laboratory for Clinical Chemistry and Haematology, Amersfoort, The Netherlands

    X
  • Ayse Y. Demir,

    Affiliation: Meander Medical Centre, Laboratory for Clinical Chemistry and Haematology, Amersfoort, The Netherlands

    X
  • Donald R. A. Uges,

    Affiliation: University of Groningen, University Medical Center, Department of Pharmacy, Laboratory for Clinical and Forensic Toxicology and Drug Analysis, Groningen, The Netherlands

    X
  • Erasto V. Mbugi,

    Affiliation: Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

    X
  • Huub F. J. Savelkoul,

    Affiliation: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands

    X
  • Hans Verhoef mail

    hans.verhoef@wur.nl

    Affiliations: Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands, MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom

    X
  • Published: November 22, 2011
  • DOI: 10.1371/journal.pmed.1001125

About the Authors

Jacobien Veenemans, Laura R. A. Schouten, Nienke Inja, Aafke C. van der Heijden, Linsey C. C. de Boer, Esther J. S. Jansen, Anna E. Koopmans, Wendy T. M. Enthoven, Huub F. J. Savelkoul, Hans Verhoef
Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands
Jacobien Veenemans
Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands
Paul Milligan
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom
Andrew M. Prentice, Hans Verhoef
MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
Andrew M. Prentice
MRC Keneba, The Gambia
Rob J. Kraaijenhagen, Ayse Y. Demir
Meander Medical Centre, Laboratory for Clinical Chemistry and Haematology, Amersfoort, The Netherlands
Donald R. A. Uges
University of Groningen, University Medical Center, Department of Pharmacy, Laboratory for Clinical and Forensic Toxicology and Drug Analysis, Groningen, The Netherlands
Erasto V. Mbugi
Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

Corresponding Author

Email: hans.verhoef@wur.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HV. Performed the experiments: JV HV LRAS NI ACvdH LCCdB EJSJ AEK WTME EVM. Analyzed the data: JV PM HV. Contributed reagents/materials/analysis tools: RJK AYD DRAU. Wrote the first draft of the manuscript: JV. Contributed to the writing of the manuscript: JV HV PM AMP. ICMJE criteria for authorship read and met: JV PM AMP LRAS NI ACvdH LCCdB EJSJ AEK WTME RJK AYD DRAU EVM HFJS HV. Agree with manuscript results and conclusions: JV PM AMP LRAS NI ACvdH LCdB EJSJ AEK WTME RJK AYD DRAU EVM HFJS HV. Enrolled patients: JV HV AEK WTME. Obtained funding: HV HFJS. Supervised the implementation of the trial: HV HFJS. Provided administrative support: HV HFJS. Critically read and approved the last version of the manuscript: LRAS NI ACvdH LCdB EJSJ AEK WTME RJK AYD DRAU EVM HFJS.