Advertisement
Research Article

Optimal Uses of Antiretrovirals for Prevention in HIV-1 Serodiscordant Heterosexual Couples in South Africa: A Modelling Study

  • Timothy B. Hallett mail,

    timothy.hallett@imperial.ac.uk

    Affiliation: Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom

    X
  • Jared M. Baeten,

    Affiliations: Department of Global Health, University of Washington, Seattle, United States of America, Department of Medicine, University of Washington, Seattle, United States of America, Department of Epidemiology, University of Washington, Seattle, United States of America

    X
  • Renee Heffron,

    Affiliations: Department of Global Health, University of Washington, Seattle, United States of America, Department of Epidemiology, University of Washington, Seattle, United States of America

    X
  • Ruanne Barnabas,

    Affiliations: Department of Global Health, University of Washington, Seattle, United States of America, Department of Medicine, University of Washington, Seattle, United States of America, Department of Epidemiology, University of Washington, Seattle, United States of America

    X
  • Guy de Bruyn,

    Affiliation: Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, South Africa

    X
  • Íde Cremin,

    Affiliation: Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom

    X
  • Sinead Delany,

    Affiliation: Reproductive Health Research Unit, University of Witwatersrand, Johannesburg, South Africa

    X
  • Geoffrey P. Garnett,

    Affiliation: Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom

    X
  • Glenda Gray,

    Affiliation: Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, South Africa

    X
  • Leigh Johnson,

    Affiliation: Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa

    X
  • James McIntyre,

    Affiliation: Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, South Africa

    X
  • Helen Rees,

    Affiliation: Reproductive Health Research Unit, University of Witwatersrand, Johannesburg, South Africa

    X
  • Connie Celum

    Affiliations: Department of Global Health, University of Washington, Seattle, United States of America, Department of Medicine, University of Washington, Seattle, United States of America, Department of Epidemiology, University of Washington, Seattle, United States of America

    X
  • Published: November 15, 2011
  • DOI: 10.1371/journal.pmed.1001123

About the Authors

Timothy B. Hallett, Íde Cremin, Geoffrey P. Garnett
Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
Jared M. Baeten, Renee Heffron, Ruanne Barnabas, Connie Celum
Department of Global Health, University of Washington, Seattle, United States of America
Jared M. Baeten, Ruanne Barnabas, Connie Celum
Department of Medicine, University of Washington, Seattle, United States of America
Jared M. Baeten, Renee Heffron, Ruanne Barnabas, Connie Celum
Department of Epidemiology, University of Washington, Seattle, United States of America
Guy de Bruyn, Glenda Gray, James McIntyre
Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, South Africa
Sinead Delany, Helen Rees
Reproductive Health Research Unit, University of Witwatersrand, Johannesburg, South Africa
Leigh Johnson
Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa

Corresponding Author

Email: timothy.hallett@imperial.ac.uk

Competing Interests

TBH has received consultancy fees from the Bill & Melinda Gates Foundation for work not directly related to the present work. GPG has in the past been a consultant in the field of Human Papilloma Virus research to Glaxo SmithKline and Merck, and has been a consultant in the field of stem cell transplantation to ViroPharma, but has no conflicts of interest in the HIV field. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TBH JB RH CC. Performed the experiments: TBH. Analyzed the data: TBH RH JB CC. Wrote the first draft of the manuscript: TBH. Contributed to the writing of the manuscript: TBH JB RH RB GB IC SD GPG GG LJ JM HR CC. ICMJE criteria for authorship read and met: TBH JB RH RB GB IC SD GPG GG LJ JM HR CC. Agree with manuscript results and conclusions: TBH JB RH RB GB IC SD GPG GG LJ JM HR CC.