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Research Article

Rapid Diagnosis of Tuberculosis with the Xpert MTB/RIF Assay in High Burden Countries: A Cost-Effectiveness Analysis

  • Anna Vassall,

    Affiliations: Department of Global Health, and Amsterdam Institute of Global Health and Development, Academic Medical Center, Amsterdam, The Netherlands, Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Sanne van Kampen,

    Affiliation: Department of Global Health, and Amsterdam Institute of Global Health and Development, Academic Medical Center, Amsterdam, The Netherlands

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  • Hojoon Sohn,

    Affiliation: Department of Epidemiology and Biostatistics, McGill University, Canada

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  • Joy S. Michael,

    Affiliation: Christian Medical College, Vellore, India

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  • K. R. John,

    Affiliation: National TB Program, Vellore, India

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  • Saskia den Boon,

    Affiliation: Makerere University - University of California, San Francisco (MU-UCSF) Research Collaboration, Kampala, Uganda

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  • J. Lucian Davis,

    Affiliation: Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, United States of America

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  • Andrew Whitelaw,

    Affiliations: National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa, Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa

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  • Mark P. Nicol,

    Affiliations: National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa, Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa

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  • Maria Tarcela Gler,

    Affiliation: Tropical Disease Foundation, Manila, Philippines

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  • Anar Khaliqov,

    Affiliation: Special Treatment Institution, Baku, Azerbaijan

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  • Carlos Zamudio,

    Affiliation: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

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  • Mark D. Perkins,

    Affiliation: Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland

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  • Catharina C. Boehme,

    Affiliation: Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland

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  • Frank Cobelens mail

    f.cobelens@aighd.org

    Affiliation: Department of Global Health, and Amsterdam Institute of Global Health and Development, Academic Medical Center, Amsterdam, The Netherlands

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  • Published: November 08, 2011
  • DOI: 10.1371/journal.pmed.1001120

About the Authors

Anna Vassall, Sanne van Kampen, Frank Cobelens
Department of Global Health, and Amsterdam Institute of Global Health and Development, Academic Medical Center, Amsterdam, The Netherlands
Anna Vassall
Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, United Kingdom
Hojoon Sohn
Department of Epidemiology and Biostatistics, McGill University, Canada
Joy S. Michael
Christian Medical College, Vellore, India
K. R. John
National TB Program, Vellore, India
Saskia den Boon
Makerere University - University of California, San Francisco (MU-UCSF) Research Collaboration, Kampala, Uganda
J. Lucian Davis
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, United States of America
Andrew Whitelaw, Mark P. Nicol
National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa
Andrew Whitelaw, Mark P. Nicol
Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
Maria Tarcela Gler
Tropical Disease Foundation, Manila, Philippines
Anar Khaliqov
Special Treatment Institution, Baku, Azerbaijan
Carlos Zamudio
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
Mark D. Perkins, Catharina C. Boehme
Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland

Corresponding Author

Email: f.cobelens@aighd.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AV Svk FC. Analyzed the data: AV Svk FC. Wrote the first draft of the manuscript: AV Svk FC. Contributed to the writing of the manuscript: AV SvK HS JSM KRJ SdB JLD AW MPN MTG AK CZ MDP CCB FC. ICMJE criteria for authorship read and met: AV SvK HS JSM KRJ SdB JLD AW MPN MTG AK CZ MDP CCB FC. Agree with manuscript results and conclusions: AV SvK HS JSM KRJ SdB JLD AW MPN MTG AK CZ MDP CCB FC. AV, Svk, and FC designed the overall study and the decision analytic model. SvK constructed the model. AV, SvK, and HS designed and carried out cost data collection. AV, SvK, and FC analyzed the final data and developed the first manuscript draft. JSM, KRJ, SdB, JLD, AW, MPN, MTG, AK, CZ, CCB, and MDP contributed to collecting and analyzing the diagnostic field data on which the decision models were based. All authors contributed to data collection, interpretation of data and revision of the article.