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Research Article

Dissecting Inflammatory Complications in Critically Injured Patients by Within-Patient Gene Expression Changes: A Longitudinal Clinical Genomics Study

  • Keyur H. Desai equal contributor,

    equal contributor Contributed equally to this work with: Keyur H. Desai, Chuen Seng Tan

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

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  • Chuen Seng Tan equal contributor,

    equal contributor Contributed equally to this work with: Keyur H. Desai, Chuen Seng Tan

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

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  • Jeffrey T. Leek,

    Affiliation: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Ronald V. Maier,

    Affiliation: Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington, United States of America

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  • Ronald G. Tompkins,

    Affiliation: Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • John D. Storey mail,

    jstorey@princeton.edu

    Affiliations: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

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  • and the Inflammation and the Host Response to Injury Large-Scale Collaborative Research Program

    Membership of the Inflammation and the Host Response to Injury Large-Scale Collaborative Research Program is provided in the Acknowledgments.

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  • Published: September 13, 2011
  • DOI: 10.1371/journal.pmed.1001093

About the Authors

Keyur H. Desai, Chuen Seng Tan, John D. Storey
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
Jeffrey T. Leek
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Ronald V. Maier
Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington, United States of America
Ronald G. Tompkins
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
John D. Storey
Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

Corresponding Author

Email: jstorey@princeton.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RVM RGT JDS. Analyzed the data: CST KHD JTL JDS. Contributed reagents/materials/analysis tools: CST KHD JTL JDS. Wrote the first draft of the manuscript: CST KHD JDS. Contributed to the writing of the manuscript: CST KHD JDS. ICMJE criteria for authorship read and met: CST KHD JTL RVM RGT JDS. Agree with manuscript results and conclusions: CST KHD JTL RVM RGT JDS. Enrolled patients: RVM RGT. The patients were collected and the expression profiling performed by investigators from the Inflammation and the Host Response to Injury Large-Scale Collaborative Research Program.