Advertisement
Research Article

IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study

  • Vijayaprakash Suppiah,

    Affiliations: Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia, Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia

    X
  • Silvana Gaudieri,

    Affiliation: Institute for Infectious Diseases, Murdoch University, Perth, Australia

    X
  • Nicola J. Armstrong,

    Affiliations: Cancer Research Program, Garvan Institute for Medical Research, University of New South Wales, Sydney, Australia, School of Mathematics and Statistics, University of New South Wales, Sydney, Australia

    X
  • Kate S. O'Connor,

    Affiliation: Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia

    X
  • Thomas Berg,

    Affiliations: Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Germany, Department of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic Leipzig, Leipzig, Germany

    X
  • Martin Weltman,

    Affiliation: Department of Gastroenterology and Hepatology, Nepean Hospital, Sydney, Australia

    X
  • Maria Lorena Abate,

    Affiliation: Liver Physiopathology Lab, Department of Internal Medicine, University of Turin, Turin, Italy

    X
  • Ulrich Spengler,

    Affiliation: Department of Internal Medicine I, University of Bonn, Bonn, Germany

    X
  • Margaret Bassendine,

    Affiliation: Liver Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • Gregory J. Dore,

    Affiliations: National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia, St Vincent's Hospital, Sydney, Australia

    X
  • William L. Irving,

    Affiliation: NIHR Biomedical Research Unit in Gastroenterology and the Liver, University of Nottingham, Nottingham, United Kingdom

    X
  • Elizabeth Powell,

    Affiliations: Princess Alexandra Hospital, Department of Gastroenterology and Hepatology, Woolloongabba, The University of Queensland, School of Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

    X
  • Margaret Hellard,

    Affiliation: Burnet Institute, Commercial Road, Melbourne, Victoria, Australia

    X
  • Stephen Riordan,

    Affiliation: Gastrointestinal and Liver Unit, Prince of Wales Hospital and University of New South Wales, Sydney, Australia

    X
  • Gail Matthews,

    Affiliations: National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia, St Vincent's Hospital, Sydney, Australia

    X
  • David Sheridan,

    Affiliation: Liver Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • Jacob Nattermann,

    Affiliation: Department of Internal Medicine I, University of Bonn, Bonn, Germany

    X
  • Antonina Smedile,

    Affiliation: Liver Physiopathology Lab, Department of Internal Medicine, University of Turin, Turin, Italy

    X
  • Tobias Müller,

    Affiliations: Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Germany, Department of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic Leipzig, Leipzig, Germany

    X
  • Emma Hammond,

    Affiliation: Institute for Infectious Diseases, Murdoch University, Perth, Australia

    X
  • David Dunn,

    Affiliation: Institute for Infectious Diseases, Murdoch University, Perth, Australia

    X
  • Francesco Negro,

    Affiliation: Divisions of Gastroenterology, Hepatology, and Clinical Pathology, University Hospitals Geneva, Switzerland

    X
  • Pierre-Yves Bochud,

    Affiliation: Divisions of Gastroenterology, Hepatology, and Clinical Pathology, University Hospitals Geneva, Switzerland

    X
  • Simon Mallal,

    Affiliation: Institute for Infectious Diseases, Murdoch University, Perth, Australia

    X
  • Golo Ahlenstiel,

    Affiliation: Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia

    X
  • Graeme J. Stewart,

    Affiliation: Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia

    X
  • Jacob George,

    Affiliation: Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia

    X
  • David R. Booth mail,

    david_booth@wmi.usyd.edu.au

    Affiliation: Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia

    X
  • for the International Hepatitis C Genetics Consortium (IHCGC)

    Contributing members of the International Hepatitis C Genetics Consortium (IHCGC) are listed in the Acknowledgments.

    X
  • Published: September 13, 2011
  • DOI: 10.1371/journal.pmed.1001092

About the Authors

Vijayaprakash Suppiah, Golo Ahlenstiel, Jacob George
Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia
Vijayaprakash Suppiah, Kate S. O'Connor, Graeme J. Stewart, David R. Booth
Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia
Silvana Gaudieri, Emma Hammond, David Dunn, Simon Mallal
Institute for Infectious Diseases, Murdoch University, Perth, Australia
Nicola J. Armstrong
Cancer Research Program, Garvan Institute for Medical Research, University of New South Wales, Sydney, Australia
Nicola J. Armstrong
School of Mathematics and Statistics, University of New South Wales, Sydney, Australia
Thomas Berg, Tobias Müller
Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Germany
Thomas Berg, Tobias Müller
Department of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic Leipzig, Leipzig, Germany
Martin Weltman
Department of Gastroenterology and Hepatology, Nepean Hospital, Sydney, Australia
Maria Lorena Abate, Antonina Smedile
Liver Physiopathology Lab, Department of Internal Medicine, University of Turin, Turin, Italy
Ulrich Spengler, Jacob Nattermann
Department of Internal Medicine I, University of Bonn, Bonn, Germany
Margaret Bassendine, David Sheridan
Liver Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
Gregory J. Dore, Gail Matthews
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
Gregory J. Dore, Gail Matthews
St Vincent's Hospital, Sydney, Australia
William L. Irving
NIHR Biomedical Research Unit in Gastroenterology and the Liver, University of Nottingham, Nottingham, United Kingdom
Elizabeth Powell
Princess Alexandra Hospital, Department of Gastroenterology and Hepatology, Woolloongabba
Elizabeth Powell
The University of Queensland, School of Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
Margaret Hellard
Burnet Institute, Commercial Road, Melbourne, Victoria, Australia
Stephen Riordan
Gastrointestinal and Liver Unit, Prince of Wales Hospital and University of New South Wales, Sydney, Australia
Francesco Negro, Pierre-Yves Bochud
Divisions of Gastroenterology, Hepatology, and Clinical Pathology, University Hospitals Geneva, Switzerland

Corresponding Author

Email: david_booth@wmi.usyd.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VS GS JG DB. Performed the experiments: VS SG EH DD DB. Analyzed the data: VS NA GA GS JG DB. Contributed reagents/materials/analysis tools: VS SG NA KO TB MW MA US MB GD WI EP MH SR GM DS JN AS TM EH DD FN PB SM GA GS JG DB. Wrote the first draft of the manuscript: DB. Contributed to the writing of the manuscript: VS SG NA KO TB MW MA US MB GD WI EP MH SR GM DS JN AS TM EH DD FN PB SM GA GS JG DB. ICMJE criteria for authorship read and met: VS SG NA KO TB MW MA US MB GD WI EP MH SR GM DS JN AS TM EH DD FN PB SM GA GS JG DB. Agree with manuscript results and conclusions: VS SG NA KO TB MW MA US MB GD WI EP MH SR GM DS JN AS TM EH DD FN PB SM GA GS JG DB. Enrolled patients: US TB MW MA US MB GD WI EP MH SR GM DS JN AS TM GA JG. Statistical authors: NA VS DB. Obtained funding: JG GS DB.