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Research Article

Effect of a Nutrition Supplement and Physical Activity Program on Pneumonia and Walking Capacity in Chilean Older People: A Factorial Cluster Randomized Trial

  • Alan D. Dangour mail,

    Alan.Dangour@lshtm.ac.uk

    Affiliation: Department of Nutrition and Public Health Intervention Research, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Cecilia Albala,

    Affiliation: Instituto de Nutrición y Tecnología de los Alimentos, University of Chile, Santiago, Chile

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  • Elizabeth Allen,

    Affiliation: Department of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Emily Grundy,

    Affiliation: Department of Population Studies, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Damian G. Walker,

    Affiliation: Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United States of America

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  • Cristian Aedo,

    Affiliation: Human Development Department, Latin America and the Caribbean Region, The World Bank, Washington (D.C.), United States of America

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  • Hugo Sanchez,

    Affiliation: Instituto de Nutrición y Tecnología de los Alimentos, University of Chile, Santiago, Chile

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  • Olivia Fletcher,

    Affiliation: Department of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Diana Elbourne,

    Affiliation: Department of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Ricardo Uauy

    Affiliation: Department of Nutrition and Public Health Intervention Research, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Published: April 19, 2011
  • DOI: 10.1371/journal.pmed.1001023

About the Authors

Alan D. Dangour, Ricardo Uauy
Department of Nutrition and Public Health Intervention Research, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
Cecilia Albala, Hugo Sanchez
Instituto de Nutrición y Tecnología de los Alimentos, University of Chile, Santiago, Chile
Elizabeth Allen, Olivia Fletcher, Diana Elbourne
Department of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
Emily Grundy
Department of Population Studies, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
Damian G. Walker
Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United States of America
Cristian Aedo
Human Development Department, Latin America and the Caribbean Region, The World Bank, Washington (D.C.), United States of America

Corresponding Author

Email: Alan.Dangour@lshtm.ac.uk

Competing Interests

Ricardo Uauy has declared: (1) I have a joint academic position between LSHTM and INTA U of Chile, the second position includes as part of my duties providing advice to the Chilean Ministry of Health on nutrition-related issues. (2) As President of the International Union of Nutritional Sciences IUNS 2005–09 I represented the IUNS providing advice on nutrition and food-related issues to the WHO, the FAO, and other UN agencies on topics related to the paper submitted to PLoS. (3) As President of the International Union of Nutritional Sciences IUNS 2005–09 I represented the IUNS in public/private partnerships; this included providing advice to industry on nutrition-related matters. No private gain was derived from these activities. IUNS policy is that these funds would be used to foster capacity in developing countries and would be disbursed by the incoming IUNS officers after I had completed my term as President. (4) I give presentations to scientific meetings that are supported by private foundations, or private sector industry and have had my travel paid by sponsors of these meetings, in topics related to nutrition and food. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AD Dangour, R Uauy. Analyzed the data: E Allen, O Fletcher, DG Walker, C Aedo. Wrote the first draft of the paper: AD Dangour, E Allen, D Elbourne, R Uauy. Wrote the paper: AD Dangour, C Albala, E Allen, E Grundy, DG Walker, C Aedo, H Sanchez, O Fletcher, D Elbourne, R Uauy. ICMJE criteria for authorship read and met: AD Dangour, C Albala, E Allen, E Grundy, DG Walker, C Aedo, H Sanchez, O Fletcher, D Elbourne, R Uauy. Agree with the manuscript′s results and conclusions: AD Dangour, C Albala, E Allen, E Grundy, DG Walker, C Aedo, H Sanchez, O Fletcher, D Elbourne, R Uauy. Applied for funding: AD Dangour, C Albala, C Aedo, E Grundy, DG Walker, R Uauy. Provided cluster trial expertise: D Elbourne. Ran the study in Chile: C Albala, H Sanchez. Designed and conducted the cost-effectiveness analysis: DG Walker, C Aedo.