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Research Article

Effect of Pneumococcal Conjugate Vaccination on Serotype-Specific Carriage and Invasive Disease in England: A Cross-Sectional Study

  • Stefan Flasche mail,

    Stefan.Flasche@hpa.org.uk

    Affiliations: Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom, Department of Mathematics and Statistics, Strathclyde University, Glasgow, United Kingdom

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  • Albert Jan Van Hoek,

    Affiliation: Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom

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  • Elizabeth Sheasby,

    Affiliation: Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom

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  • Pauline Waight,

    Affiliation: Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom

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  • Nick Andrews,

    Affiliation: Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom

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  • Carmen Sheppard,

    Affiliation: Respiratory & Systemic Infection Laboratory (RSIL), Health Protection Agency, London, United Kingdom

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  • Robert George,

    Affiliation: Respiratory & Systemic Infection Laboratory (RSIL), Health Protection Agency, London, United Kingdom

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  • Elizabeth Miller

    Affiliation: Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom

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  • Published: April 05, 2011
  • DOI: 10.1371/journal.pmed.1001017

About the Authors

Stefan Flasche, Albert Jan Van Hoek, Elizabeth Sheasby, Pauline Waight, Nick Andrews, Elizabeth Miller
Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
Stefan Flasche
Department of Mathematics and Statistics, Strathclyde University, Glasgow, United Kingdom
Carmen Sheppard, Robert George
Respiratory & Systemic Infection Laboratory (RSIL), Health Protection Agency, London, United Kingdom

Corresponding Author

Email: Stefan.Flasche@hpa.org.uk

Competing Interests

RG and CS have received support from Wyeth vaccines (now Pfizer) for conference attendance. SF, PW, AJVH, ES, NA, and EM declare no competing interests.

Author Contributions

Analyzed the data: SF NA. Wrote the first draft: SF AJVH EM. Wrote the manuscript: SF AJVH LS PW CS RG EM. ICMJE criteria for authorship read and met: SF AJVH LS PW CS RG EM NA. Agree with the results and conclusions: SF AJVH LS PW CS RG EM NA. Designed the study: AJVH NA EM. Oversaw the field work: LS. Database design and study data management: PW. Culture and serotyping: CS RG.