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Research Article

Low-Dose Adrenaline, Promethazine, and Hydrocortisone in the Prevention of Acute Adverse Reactions to Antivenom following Snakebite: A Randomised, Double-Blind, Placebo-Controlled Trial

  • H. Asita de Silva mail,

    asita@sltnet.lk

    Affiliation: Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

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  • Arunasalam Pathmeswaran,

    Affiliation: Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

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  • Channa D. Ranasinha,

    Affiliation: Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

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  • Shaluka Jayamanne,

    Affiliation: Polonnaruwa General Hospital, Polonnaruwa, Sri Lanka

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  • Senarath B. Samarakoon,

    Affiliation: Polonnaruwa General Hospital, Polonnaruwa, Sri Lanka

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  • Ariyasena Hittharage,

    Affiliation: Kurunegala Teaching Hospital, Kurunegala, Sri Lanka

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  • Ranjith Kalupahana,

    Affiliation: Kurunegala Teaching Hospital, Kurunegala, Sri Lanka

    X
  • G. Asoka Ratnatilaka,

    Affiliation: Kurunegala Teaching Hospital, Kurunegala, Sri Lanka

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  • Wimalasiri Uluwatthage,

    Affiliation: Hambantota General Hospital, Hambantota, Sri Lanka

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  • Jeffrey K. Aronson,

    Affiliation: Department of Primary Health Care, University of Oxford, Oxford, United Kingdom

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  • Jane M. Armitage,

    Affiliation: Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom

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  • David G. Lalloo,

    Affiliation: Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • H. Janaka de Silva

    Affiliation: Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

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  • Published: May 10, 2011
  • DOI: 10.1371/journal.pmed.1000435

About the Authors

H. Asita de Silva, Arunasalam Pathmeswaran, Channa D. Ranasinha, H. Janaka de Silva
Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
Shaluka Jayamanne, Senarath B. Samarakoon
Polonnaruwa General Hospital, Polonnaruwa, Sri Lanka
Ariyasena Hittharage, Ranjith Kalupahana, G. Asoka Ratnatilaka
Kurunegala Teaching Hospital, Kurunegala, Sri Lanka
Wimalasiri Uluwatthage
Hambantota General Hospital, Hambantota, Sri Lanka
Jeffrey K. Aronson
Department of Primary Health Care, University of Oxford, Oxford, United Kingdom
Jane M. Armitage
Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
David G. Lalloo
Liverpool School of Tropical Medicine, Liverpool, United Kingdom

Corresponding Author

Email: asita@sltnet.lk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: HAdS AP CDR SJ SBS AH RK GAR WU JKA JMA DGL HJdS. Agree with the manuscript's results and conclusions: HAdS AP CDR SJ SBS AH RK GAR WU JKA JMA DGL HJdS. Designed the experiments/the study: HAdS CDR AH JKA JMA DGL HJdS. Analyzed the data: HAdS AP JKA JMA DGL. Collected data/did experiments for the study: HAdS SJ SBS AH RK GAR WU. Enrolled patients: HAdS SJ SBS AH RK GAR WU. Wrote the first draft of the paper: HAdS CDR HJdS. Contributed to the writing of the paper: HAdS AP CDR SJ SBS JKA DGL HJdS. Provided comments on the manuscript: JMA. Participated in the design; supervised the study: HJdS.