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Research Article

Intermittent Preventive Treatment of Malaria Provides Substantial Protection against Malaria in Children Already Protected by an Insecticide-Treated Bednet in Mali: A Randomised, Double-Blind, Placebo-Controlled Trial

  • Alassane Dicko mail,

    adicko@icermali.org

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Abdoulbaki I. Diallo,

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Intimbeye Tembine,

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Yahia Dicko,

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Niawanlou Dara,

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Youssoufa Sidibe,

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Gaoussou Santara,

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Halimatou Diawara,

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Toumani Conaré,

    Affiliation: Centre de Santé de Référence de Kati, Kati, Mali

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  • Abdoulaye Djimde,

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Daniel Chandramohan,

    Affiliation: London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Simon Cousens,

    Affiliation: London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Paul J. Milligan,

    Affiliation: London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Diadier A. Diallo,

    Affiliation: London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Ogobara K. Doumbo,

    Affiliation: Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Brian Greenwood

    Affiliation: London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Published: February 01, 2011
  • DOI: 10.1371/journal.pmed.1000407

About the Authors

Alassane Dicko, Abdoulbaki I. Diallo, Intimbeye Tembine, Yahia Dicko, Niawanlou Dara, Youssoufa Sidibe, Gaoussou Santara, Halimatou Diawara, Abdoulaye Djimde, Ogobara K. Doumbo
Malaria Research and Training Centre, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, Bamako, Mali
Toumani Conaré
Centre de Santé de Référence de Kati, Kati, Mali
Daniel Chandramohan, Simon Cousens, Paul J. Milligan, Diadier A. Diallo, Brian Greenwood
London School of Hygiene & Tropical Medicine, London, United Kingdom

Corresponding Author

Email: adicko@icermali.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: A Dicko, AI Diallo, I Tembine, Y Dicko, N Dara, Y Sidibe, G Santara, H Diawara, T Conaré, A Djimde, D Chandramohan, S Cousens, PJ Milligan, DA Diallo, OK Doumbo, B Greenwood. Agree with the manuscript's results and conclusions: A Dicko, AI Diallo, I Tembine, Y Dicko, N Dara, Y Sidibe, G Santara, H Diawara, T Conaré, A Djimde, D Chandramohan, S Cousens, PJ Milligan, DA Diallo, OK Doumbo, B Greenwood. Designed the experiments/the study: A Dicko, T Conaré, D Chandramohan, S Cousens, PJ Milligan, DA Diallo, OK Doumbo, B Greenwood. Analyzed the data: A Dicko, PJ Milligan, DA Diallo. Collected data/did experiments for the study: A Dicko, AI Diallo, I Tembine, Y Dicko, N Dara, Y Sidibe, G Santara, H Diawara, A Djimde. Enrolled patients: A Dicko, I Tembine, Y Dicko, Y Sidibe, G Santara. Wrote the first draft of the paper: A Dicko. Contributed to the writing of the paper: A Dicko, AI Diallo, I Tembine, Y Dicko, N Dara, Y Sidibe, G Santara, H Diawara, T Conaré, A Djimde, D Chandramohan, S Cousens, PJ Milligan, DA Diallo, OK Doumbo, B Greenwood. Oversaw the overall implementation of the trial: DA Diallo.