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Research Article

Clinical Features and Serum Biomarkers in HIV Immune Reconstitution Inflammatory Syndrome after Cryptococcal Meningitis: A Prospective Cohort Study

  • David R. Boulware mail,

    boulw001@umn.edu

    Affiliations: Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • David B. Meya,

    Affiliations: Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America, Infectious Disease Institute, Makerere University, Kampala, Uganda

    X
  • Tracy L. Bergemann,

    Affiliation: Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Darin L. Wiesner,

    Affiliation: Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Joshua Rhein,

    Affiliations: Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Abdu Musubire,

    Affiliation: Infectious Disease Institute, Makerere University, Kampala, Uganda

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  • Sarah J. Lee,

    Affiliation: Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Andrew Kambugu,

    Affiliations: Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America, Infectious Disease Institute, Makerere University, Kampala, Uganda

    X
  • Edward N. Janoff,

    Affiliation: Mucosal and Vaccine Research Program Colorado (MAVRC), Division of Infectious Diseases, University of Colorado Denver School of Medicine, Denver Veterans Affairs Medical Center, Denver, Colorado, United States of America

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  • Paul R. Bohjanen

    Affiliations: Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Published: December 21, 2010
  • DOI: 10.1371/journal.pmed.1000384

About the Authors

David R. Boulware, David B. Meya, Joshua Rhein, Sarah J. Lee, Andrew Kambugu, Paul R. Bohjanen
Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America
David R. Boulware, Darin L. Wiesner, Joshua Rhein, Paul R. Bohjanen
Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, Minnesota, United States of America
David B. Meya, Abdu Musubire, Andrew Kambugu
Infectious Disease Institute, Makerere University, Kampala, Uganda
Tracy L. Bergemann
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America
Edward N. Janoff
Mucosal and Vaccine Research Program Colorado (MAVRC), Division of Infectious Diseases, University of Colorado Denver School of Medicine, Denver Veterans Affairs Medical Center, Denver, Colorado, United States of America
Paul R. Bohjanen
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, United States of America

Corresponding Author

Email: boulw001@umn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: DRB DBM TLB DLW JR AM SJL AK ENJ PRB. Agree with the manuscript's results and conclusions: DRB DBM TLB DLW JR AM SJL AK ENJ PRB. Designed the experiments/the study: DRB DBM JR AK ENJ PRB. Analyzed the data: DRB TLB SJL ENJ PRB. Collected data/did experiments for the study: DRB DBM DLW JR AM SJL. Enrolled patients: DBM JR AM. Wrote the first draft of the paper: DRB DBM. Contributed to the writing of the paper: DRB DBM TLB DLW JR AM ENJ PRB. Primary statistician: TLB. Substantial analytic contributions and model development: ENJ.