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Research Article

Air Pollution and the Microvasculature: A Cross-Sectional Assessment of In Vivo Retinal Images in the Population-Based Multi-Ethnic Study of Atherosclerosis (MESA)

  • Sara D. Adar mail,

    sadar@umich.edu

    Affiliations: Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Ronald Klein,

    Affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Barbara E. K. Klein,

    Affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Adam A. Szpiro,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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  • Mary Frances Cotch,

    Affiliation: Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland, United States of America

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  • Tien Y. Wong,

    Affiliations: Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia, Singapore Eye Research Institute, National University of Singapore, Singapore

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  • Marie S. O'Neill,

    Affiliations: Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Sandi Shrager,

    Affiliation: Singapore Eye Research Institute, National University of Singapore, Singapore

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  • R. Graham Barr,

    Affiliation: Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, New York, United States of America

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  • David S. Siscovick,

    Affiliations: Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Martha L. Daviglus,

    Affiliation: Department of Preventive Medicine and Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Paul D. Sampson,

    Affiliation: Department of Statistics, University of Washington, Seattle, Washington, United States of America

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  • Joel D. Kaufman

    Affiliations: Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Published: November 30, 2010
  • DOI: 10.1371/journal.pmed.1000372

About the Authors

Sara D. Adar, David S. Siscovick, Joel D. Kaufman
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
Sara D. Adar, Joel D. Kaufman
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America
Sara D. Adar, Marie S. O'Neill
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America
Ronald Klein, Barbara E. K. Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
Adam A. Szpiro
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Mary Frances Cotch
Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland, United States of America
Tien Y. Wong
Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia
Tien Y. Wong, Sandi Shrager
Singapore Eye Research Institute, National University of Singapore, Singapore
Marie S. O'Neill
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, United States of America
R. Graham Barr
Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, New York, United States of America
David S. Siscovick, Joel D. Kaufman
Department of Medicine, University of Washington, Seattle, Washington, United States of America
Martha L. Daviglus
Department of Preventive Medicine and Medicine, Northwestern University, Chicago, Illinois, United States of America
Paul D. Sampson
Department of Statistics, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: sadar@umich.edu

Competing Interests

Several authors (SDA, AAS, MSO, RGB, DSS, PDS, and JDK) have received unrestricted grant funding or support on unrestricted grant funds to study related topics from the Environmental Protection Agency, National Institutes of Heath, and/or the Health Effects Institute.

Author Contributions

ICMJE criteria for authorship read and met: SDA RK BEKK AAS MFC TYW MSO SS RGB DSS MLD PDS JDK. Agree with the manuscript's results and conclusions: SDA RK BEKK AAS MFC TYW MSO SS RGB DSS MLD PDS JDK. Designed the experiments/the study: SDA MFC DSS JDK. Analyzed the data: SDA AAS SS. Collected data/did experiments for the study: RK BEKK SS RGB MLD. Enrolled patients: RGB MLD. Wrote the first draft of the paper: SDA. Contributed to the writing of the paper: SDA RK BEKK AAS MFC TYW MSO SS RGB DSS MLD PDS JDK. Critically revised manuscript for important intellectual content: BEKK. Developed statistical models: AAS. Helped to develop the collaboration with MESA that led to MESA AIR, and helped obtain funding for MESA AIR from the EPA: DSS. Reviewed the results of various analyses and suggested additional analyses: DSS. Responsible for the spatio-temporal model and estimates of exposure: PDS.