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Research Article

A Genetic Association Study of Serum Acute-Phase C-Reactive Protein Levels in Rheumatoid Arthritis: Implications for Clinical Interpretation

  • Benjamin Rhodes,

    Affiliation: Rheumatology Section, Division of Medicine, Imperial College London, London, United Kingdom

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  • Marilyn E. Merriman,

    Affiliation: Department of Biochemistry, University of Otago, Dunedin, New Zealand

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  • Andrew Harrison,

    Affiliation: Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Dunedin, New Zealand

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  • Michael J. Nissen,

    Affiliation: Rheumatology Unit, Repatriation General Hospital, Daw Park, Adelaide, South Australia, Australia

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  • Malcolm Smith,

    Affiliation: Rheumatology Unit, Repatriation General Hospital, Daw Park, Adelaide, South Australia, Australia

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  • Lisa Stamp,

    Affiliation: Department of Medicine, University of Otago, Christchurch, New Zealand

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  • Sophia Steer,

    Affiliation: Clinical and Academic Rheumatology, Kings College Hospital NHS Foundation Trust, London, United Kingdom

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  • Tony R. Merriman,

    Affiliation: Department of Biochemistry, University of Otago, Dunedin, New Zealand

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  • Timothy J. Vyse mail

    t.vyse@imperial.ac.uk

    Affiliation: Rheumatology Section, Division of Medicine, Imperial College London, London, United Kingdom

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  • Published: September 21, 2010
  • DOI: 10.1371/journal.pmed.1000341

About the Authors

Benjamin Rhodes, Timothy J. Vyse
Rheumatology Section, Division of Medicine, Imperial College London, London, United Kingdom
Marilyn E. Merriman, Tony R. Merriman
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Andrew Harrison
Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Dunedin, New Zealand
Michael J. Nissen, Malcolm Smith
Rheumatology Unit, Repatriation General Hospital, Daw Park, Adelaide, South Australia, Australia
Lisa Stamp
Department of Medicine, University of Otago, Christchurch, New Zealand
Sophia Steer
Clinical and Academic Rheumatology, Kings College Hospital NHS Foundation Trust, London, United Kingdom

Corresponding Author

Email: t.vyse@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: BR MEM AH MJN MS LS SS TRM TJV. Agree with the manuscript's results and conclusions: BR MEM AH MJN MS LS SS TRM TJV. Designed the experiments/the study: BR TJV. Analyzed the data: BR TJV. Collected data/did experiments for the study: BR MEM AH MJN MS LS SS TRM. Enrolled patients: AH MJN MS LS SS. Wrote the first draft of the paper: BR. Contributed to the writing of the paper: BR MEM AH MJN MS LS SS TRM TJV. Responsible for preparing data (and checking of data integrity) from New Zealand and Australian samples included in the analysis: MEM.