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Research Article

Major Radiodiagnostic Imaging in Pregnancy and the Risk of Childhood Malignancy: A Population-Based Cohort Study in Ontario

  • Joel G. Ray mail,

    rayj@smh.toronto.on.ca

    Affiliations: Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada, Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, Ontario, Canada, Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada, Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada

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  • Michael J. Schull,

    Affiliations: Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada, Department of Medicine (Division of Emergency Medicine), Sunnybrook Sciences Centre, Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada

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  • Marcelo L. Urquia,

    Affiliation: Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

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  • John J. You,

    Affiliations: Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada, Department of Medicine, McMaster University, Hamilton, Ontario, Canada, Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada

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  • Astrid Guttmann,

    Affiliations: Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada, Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Marian J. Vermeulen

    Affiliation: Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada

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  • Published: September 07, 2010
  • DOI: 10.1371/journal.pmed.1000337
  • Featured in PLOS Collections

About the Authors

Joel G. Ray
Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada
Joel G. Ray
Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, Ontario, Canada
Joel G. Ray, Michael J. Schull, Astrid Guttmann
Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
Joel G. Ray, John J. You, Astrid Guttmann, Marian J. Vermeulen
Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
Michael J. Schull
Department of Medicine (Division of Emergency Medicine), Sunnybrook Sciences Centre, Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
Marcelo L. Urquia
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
John J. You
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
John J. You
Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada
Astrid Guttmann
Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada

Corresponding Author

Email: rayj@smh.toronto.on.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: JGR MJS MLU JJY AG MJV. Agree with the manuscript's results and conclusions: JGR MJS MLU JJY AG MJV. Designed the experiments/the study: JGR AG. Analyzed the data: JGR MJV. Collected data/did experiments for the study: JGR. Enrolled patients: JGR. Wrote the first draft of the paper: JGR. Contributed to the writing of the paper: JGR MJS MLU JJY AG MJV. Contributed to the design and interpretation of results: MLU. Contributed to the development of the analysis plan: JJY. Contributed to the design of the study: MJV.