Advertisement
Research Article

Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study

  • Shengxu Li,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

    X
  • Jing Hua Zhao,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

    X
  • Jian'an Luan,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

    X
  • Ulf Ekelund,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

    X
  • Robert N. Luben,

    Affiliation: Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom

    X
  • Kay-Tee Khaw,

    Affiliation: Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom

    X
  • Nicholas J. Wareham,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

    X
  • Ruth J. F. Loos mail

    ruth.loos@mrc-epid.cam.ac.uk

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

    X
  • Published: August 31, 2010
  • DOI: 10.1371/journal.pmed.1000332

About the Authors

Shengxu Li, Jing Hua Zhao, Jian'an Luan, Ulf Ekelund, Nicholas J. Wareham, Ruth J. F. Loos
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
Robert N. Luben, Kay-Tee Khaw
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: ruth.loos@mrc-epid.cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: SL JHZ JL UE RNL KTK NJW RJFL. Agree with the manuscript's results and conclusions: SL JHZ JL UE RNL KTK NJW RJFL. Designed the experiments/the study: SL RNL KTK NJW RJFL. Analyzed the data: SL JHZ JL. Collected data/did experiments for the study: JL KTK NJW. Enrolled patients: KTK NJW. Wrote the first draft of the paper: SL. Contributed to the writing of the paper: SL JHZ UE KTK NJW RJFL. Involved in design and analysis of the genome-wide association data associated with the EPIC-Norfolk study: JHZ. Contributed to the interpretation of the data: UE. Conception and design of the study and the acquisition of the data: RNL.