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Challenges in Developing Evidence-Based Recommendations Using the GRADE Approach: The Case of Mental, Neurological, and Substance Use Disorders

  • Corrado Barbui mail,

    corrado.barbui@univr.it

    Affiliation: Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy

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  • Tarun Dua,

    Affiliation: Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland

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  • Mark van Ommeren,

    Affiliation: Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland

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  • M. Taghi Yasamy,

    Affiliation: Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland

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  • Alexandra Fleischmann,

    Affiliation: Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland

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  • Nicolas Clark,

    Affiliation: Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland

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  • Graham Thornicroft,

    Affiliation: Health Services Research Department, Institute of Psychiatry, King's College, London, United Kingdom

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  • Suzanne Hill,

    Affiliation: Essential Medicines and Pharmaceutical Policies, World Health Organization, Geneva, Switzerland

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  • Shekhar Saxena

    Affiliation: Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland

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  • Published: August 31, 2010
  • DOI: 10.1371/journal.pmed.1000322

About the Authors

Corrado Barbui
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
Tarun Dua, Mark van Ommeren, M. Taghi Yasamy, Alexandra Fleischmann, Nicolas Clark, Shekhar Saxena
Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland
Graham Thornicroft
Health Services Research Department, Institute of Psychiatry, King's College, London, United Kingdom
Suzanne Hill
Essential Medicines and Pharmaceutical Policies, World Health Organization, Geneva, Switzerland

Corresponding Author

Email: corrado.barbui@univr.it

Competing Interests

SH is a member of the GRADE working group on methods for guideline development and currently chairs the WHO Guideline Review Committee that sets standards for WHO guideline development. TD, MvO, MTY, AF, NC, SH, and SS alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions, policy, or views of the World Health Organization.

Author Contributions

ICMJE criteria for authorship read and met: CB TD MVO MTY AF NC GT SH SS. Agree with the manuscript's results and conclusions: CB TD MVO MTY AF NC GT SH SS. Wrote the first draft of the paper: CB. Contributed to the writing of the paper: CB TD MVO MTY AF NC GT SH SS. Contributed to all three stages of the preparation.