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Research Article

Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma

  • William W. Lockwood mail,

    wlockwood@bccrc.ca

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Raj Chari,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Bradley P. Coe,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Kelsie L. Thu,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Cathie Garnis,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Chad A. Malloff,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Jennifer Campbell,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Ariane C. Williams,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Dorothy Hwang,

    Affiliation: Department of Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Chang-Qi Zhu,

    Affiliation: Department of Pathology, Division of Applied Molecular Oncology, University Health Network - Princess Margaret Hospital and Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada

    X
  • Timon P. H. Buys,

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • John Yee,

    Affiliation: Department of Surgery, Vancouver General Hospital, Vancouver, British Columbia

    X
  • John C. English,

    Affiliation: Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia

    X
  • Calum MacAulay,

    Affiliation: Department of Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Ming-Sound Tsao,

    Affiliation: Department of Pathology, Division of Applied Molecular Oncology, University Health Network - Princess Margaret Hospital and Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada

    X
  • Adi F. Gazdar,

    Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas

    X
  • John D. Minna,

    Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas

    X
  • Stephen Lam,

    Affiliation: Department of Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Wan L. Lam

    Affiliation: Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Published: July 27, 2010
  • DOI: 10.1371/journal.pmed.1000315

About the Authors

William W. Lockwood, Raj Chari, Bradley P. Coe, Kelsie L. Thu, Cathie Garnis, Chad A. Malloff, Jennifer Campbell, Ariane C. Williams, Timon P. H. Buys, Wan L. Lam
Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
Dorothy Hwang, Calum MacAulay, Stephen Lam
Department of Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
Chang-Qi Zhu, Ming-Sound Tsao
Department of Pathology, Division of Applied Molecular Oncology, University Health Network - Princess Margaret Hospital and Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
John Yee
Department of Surgery, Vancouver General Hospital, Vancouver, British Columbia
John C. English
Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia
Adi F. Gazdar, John D. Minna
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas

Corresponding Author

Email: wlockwood@bccrc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: WWL RC BPC KLT CG CAM JC ACW DH CQZ TPB JY JCE CM MST AFG JDM SL WLL. Agree with the manuscript's results and conclusions: WWL RC BPC KLT CG CAM JC ACW DH CQZ TPB JY JCE CM MST AFG JDM SL WLL. Designed the experiments/the study: WWL KLT DH TPB WLL. Analyzed the data: WWL RC BPC KLT JC CQZ AFG WLL. Collected data/did experiments for the study: WWL KLT CG CAM JC ACW DH CQZ TPB JY JCE. Enrolled patients: JY SL. Wrote the first draft of the paper: WWL. Contributed to the writing of the paper: WWL RC BPC KLT JC ACW JY JCE CM AFG JDM SL WLL. Contributed tumor samples, review data, study results, and manuscript drafts/final version: MST. Contributed unique reagents and cell lines for the study, helped design the experiments, and analyzed the data: AFG. Provided lung cancer cell lines and immortalized normal human bronchial epithelial cell lines for key functional tests: JDM.