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Research Article

A Six-Gene Signature Predicts Survival of Patients with Localized Pancreatic Ductal Adenocarcinoma

  • Jeran K. Stratford,

    Affiliation: Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • David J. Bentrem,

    Affiliation: Department of Surgery and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Judy M. Anderson,

    Affiliation: The Eppley Cancer Institute, University of Nebraska, Omaha, Nebraska, United States of America

    X
  • Cheng Fan,

    Affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Keith A. Volmar,

    Affiliation: Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • J. S. Marron,

    Affiliations: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Elizabeth D. Routh,

    Affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Laura S. Caskey,

    Affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Jonathan C. Samuel,

    Affiliation: Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Channing J. Der,

    Affiliations: Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Leigh B. Thorne,

    Affiliations: Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Benjamin F. Calvo,

    Affiliations: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Hong Jin Kim,

    Affiliations: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Mark S. Talamonti,

    Affiliation: Department of Surgery, NorthShore University HealthSystem, Baltimore, Maryland, United States of America

    X
  • Christine A. Iacobuzio-Donahue,

    Affiliation: Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

    X
  • Michael A. Hollingsworth,

    Affiliation: The Eppley Cancer Institute, University of Nebraska, Omaha, Nebraska, United States of America

    X
  • Charles M. Perou,

    Affiliations: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Jen Jen Yeh mail

    jjyeh@med.unc.edu

    Affiliations: Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Published: July 13, 2010
  • DOI: 10.1371/journal.pmed.1000307

About the Authors

Jeran K. Stratford, Channing J. Der, Jen Jen Yeh
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
David J. Bentrem
Department of Surgery and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America
Judy M. Anderson, Michael A. Hollingsworth
The Eppley Cancer Institute, University of Nebraska, Omaha, Nebraska, United States of America
Cheng Fan, J. S. Marron, Elizabeth D. Routh, Laura S. Caskey, Channing J. Der, Benjamin F. Calvo, Hong Jin Kim, Charles M. Perou, Jen Jen Yeh
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Keith A. Volmar, Leigh B. Thorne
Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
J. S. Marron, Leigh B. Thorne
Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Jonathan C. Samuel, Benjamin F. Calvo, Hong Jin Kim, Jen Jen Yeh
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Mark S. Talamonti
Department of Surgery, NorthShore University HealthSystem, Baltimore, Maryland, United States of America
Christine A. Iacobuzio-Donahue
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Charles M. Perou
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: jjyeh@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: JKS DJB JMA CF KAV JSM EDR LSC JCS CJD LBT BFC HJK MST CAID MAH CMP JJY. Agree with the manuscript's results and conclusions: JKS DJB JMA CF KAV JSM EDR LSC JCS CJD LBT BFC HJK MST CAID MAH CMP JJY. Designed the experiments/the study: JKS MAH JJY. Analyzed the data: JKS CF JSM CMP JJY. Collected data/did experiments for the study: JKS DJB JMA KAV EDR LSC JCS HJK JJY. Enrolled patients: DJB BFC HJK MST CAID JJY. Wrote the first draft of the paper: JJY. Contributed to the writing of the paper: JKS DJB CF JSM CJD HJK MST MAH CMP JJY. Created figures for the paper: JSM. Responsible for tissue procurement: LBT. Prepared tissue microarray: LBT.