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Research Article

Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease

  • Harry Hemingway mail,

    h.hemingway@ucl.ac.uk

    Affiliation: Department of Epidemiology and Public Health, University College London, United Kingdom

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  • Peter Philipson,

    Affiliation: Department of Epidemiology and Public Health, University College London, United Kingdom

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  • Ruoling Chen,

    Affiliation: Department of Epidemiology and Public Health, University College London, United Kingdom

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  • Natalie K. Fitzpatrick,

    Affiliation: Department of Epidemiology and Public Health, University College London, United Kingdom

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  • Jacqueline Damant,

    Affiliation: Department of Epidemiology and Public Health, University College London, United Kingdom

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  • Martin Shipley,

    Affiliation: Department of Epidemiology and Public Health, University College London, United Kingdom

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  • Keith R. Abrams,

    Affiliation: Department of Health Sciences, University of Leicester, United Kingdom

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  • Santiago Moreno,

    Affiliation: Department of Health Sciences, University of Leicester, United Kingdom

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  • Kate S. L. McAllister,

    Affiliation: Department of Epidemiology and Public Health, University College London, United Kingdom

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  • Stephen Palmer,

    Affiliation: Centre for Health Economics, University of York, United Kingdom

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  • Juan Carlos Kaski,

    Affiliation: St George's University of London, United Kingdom

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  • Adam D. Timmis,

    Affiliation: Barts and the London Medical School, United Kingdom

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  • Aroon D. Hingorani

    Affiliation: Department of Epidemiology and Public Health, University College London, United Kingdom

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  • Published: June 01, 2010
  • DOI: 10.1371/journal.pmed.1000286

About the Authors

Harry Hemingway, Peter Philipson, Ruoling Chen, Natalie K. Fitzpatrick, Jacqueline Damant, Martin Shipley, Kate S. L. McAllister, Aroon D. Hingorani
Department of Epidemiology and Public Health, University College London, United Kingdom
Keith R. Abrams, Santiago Moreno
Department of Health Sciences, University of Leicester, United Kingdom
Stephen Palmer
Centre for Health Economics, University of York, United Kingdom
Juan Carlos Kaski
St George's University of London, United Kingdom
Adam D. Timmis
Barts and the London Medical School, United Kingdom

Corresponding Author

Email: h.hemingway@ucl.ac.uk

Competing Interests

ADH is on the editorial board of Drug and Therapeutics Bulletin, a BMJ Group Publication; acts as a scientific advisor to London Genetics; has provided non-remunerated advice to GlaxoSmithKline; and has previously received honoraria for speaking at educational meetings on cardiovascular risk and has donated these in whole or part to charity.

Author Contributions

ICMJE criteria for authorship read and met: HH PMP RC NKF JD MS KRA SM KSLM SP JCK ADT AH. Agree with the manuscript's results and conclusions: HH PMP RC NKF JD MS KRA SM KSLM SP JCK ADT AH. Designed the experiments/the study: HH RC KRA SP. Analyzed the data: PMP RC MS KRA SM. Collected data/did experiments for the study: RC NKF JD KSLM. Wrote the first draft of the paper: HH. Contributed to the writing of the paper: HH PMP RC NKF JD MS KRA SM KSLM SP JCK ADT AH. Contributed to analysis and interpretation of the data: ADT. Co-applicant and contributor to the grant proposal that funded the work: ADH. Contributed to the discussions on the design and interpretation of the study: ADH.