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Research Article

Genetic Markers of Adult Obesity Risk Are Associated with Greater Early Infancy Weight Gain and Growth

  • Cathy E. Elks,

    Affiliations: MRC Epidemiology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Ruth J. F. Loos,

    Affiliations: MRC Epidemiology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Stephen J. Sharp,

    Affiliations: MRC Epidemiology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Claudia Langenberg,

    Affiliations: MRC Epidemiology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Susan M. Ring,

    Affiliation: Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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  • Nicholas J. Timpson,

    Affiliation: MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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  • Andrew R. Ness,

    Affiliation: Department of Oral and Dental Science, University of Bristol, Bristol, United Kingdom

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  • George Davey Smith,

    Affiliation: MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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  • David B. Dunger,

    Affiliation: Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom

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  • Nicholas J. Wareham,

    Affiliations: MRC Epidemiology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Ken K. Ong mail

    ken.ong@mrc-epid.cam.ac.uk

    Affiliations: MRC Epidemiology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom, Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom

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  • Published: May 25, 2010
  • DOI: 10.1371/journal.pmed.1000284

About the Authors

Cathy E. Elks, Ruth J. F. Loos, Stephen J. Sharp, Claudia Langenberg, Nicholas J. Wareham, Ken K. Ong
MRC Epidemiology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom
Cathy E. Elks, Ruth J. F. Loos, Stephen J. Sharp, Claudia Langenberg, Nicholas J. Wareham, Ken K. Ong
Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
Susan M. Ring
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Nicholas J. Timpson, George Davey Smith
MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Andrew R. Ness
Department of Oral and Dental Science, University of Bristol, Bristol, United Kingdom
David B. Dunger, Ken K. Ong
Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: ken.ong@mrc-epid.cam.ac.uk

Competing Interests

George Davey Smith is on the Editorial Board of PLoS Medicine.

Author Contributions

ICMJE criteria for authorship read and met: CEE RJFL SS CL SMR NJT ARN GDS DBD NJW KKO. Agree with the manuscript's results and conclusions: CEE RJFL SS CL SMR NJT ARN GDS DBD NJW KKO. Designed the experiments/the study: RJFL GDS DBD NJW KKO. Analyzed the data: CEE GDS KKO. Collected data/did experiments for the study: SMR GDS NJW KKO. Enrolled patients: GDS. Wrote the first draft of the paper: CEE KKO. Contributed to the writing of the paper: CEE RJFL SS CL SMR NJT ARN GDS NJW KKO. This publication is the responsibility of Ken Ong and George Davey-Smith, who had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.