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Research Article

The Impact of Phenotypic and Genotypic G6PD Deficiency on Risk of Plasmodium vivax Infection: A Case-Control Study amongst Afghan Refugees in Pakistan

  • Toby Leslie mail,

    toby.leslie@lshtm.ac.uk

    Affiliations: Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom, HeathNet TPO, Peshawar, North West Frontier Province, Pakistan

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  • Marnie Briceño,

    Affiliation: Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Ismail Mayan,

    Affiliation: HeathNet TPO, Peshawar, North West Frontier Province, Pakistan

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  • Nasir Mohammed,

    Affiliation: HeathNet TPO, Peshawar, North West Frontier Province, Pakistan

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  • Eveline Klinkenberg,

    Affiliation: HealthNet TPO, Amsterdam, The Netherlands

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  • Carol Hopkins Sibley,

    Affiliation: Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Christopher J. M. Whitty,

    Affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Mark Rowland

    Affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Published: May 25, 2010
  • DOI: 10.1371/journal.pmed.1000283

About the Authors

Toby Leslie, Christopher J. M. Whitty, Mark Rowland
Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom
Toby Leslie, Ismail Mayan, Nasir Mohammed
HeathNet TPO, Peshawar, North West Frontier Province, Pakistan
Marnie Briceño, Carol Hopkins Sibley
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
Eveline Klinkenberg
HealthNet TPO, Amsterdam, The Netherlands

Corresponding Author

Email: toby.leslie@lshtm.ac.uk

Competing Interests

Other than the partial funding by GlaxoSmithKline of this investigator-initiated study, CJMW has received funding for investigator -initiated research from Pfizer. None of the other authors have conflicts of interest to declare.

Author Contributions

ICMJE criteria for authorship read and met: TL MB IM NM EK CHS CJMW MR. Agree with the manuscript's results and conclusions: TL MB IM NM EK CHS CJMW MR. Designed the experiments/the study: TL IM EK CJMW MR. Analyzed the data: TL MB EK CHS CJMW MR. Collected data/did experiments for the study: TL MB IM NM CHS. Enrolled patients: NM. Wrote the first draft of the paper: TL. Contributed to the writing of the paper: TL MB IM EK CHS CJMW MR. Planned and executed molecular analysis, analyzed molecular data, and edited final draft: CHS.