Advertisement
Research Article

Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies

  • Fiona M. Blows equal contributor,

    equal contributor Contributed equally to this work with: Fiona M. Blows, Kristy E. Driver

    Affiliation: Department of Oncology, University of Cambridge, United Kingdom

    X
  • Kristy E. Driver equal contributor,

    equal contributor Contributed equally to this work with: Fiona M. Blows, Kristy E. Driver

    Affiliation: Department of Oncology, University of Cambridge, United Kingdom

    X
  • Marjanka K. Schmidt,

    Affiliation: Netherlands Cancer Institute, Amsterdam, The Netherlands

    X
  • Annegien Broeks,

    Affiliation: Netherlands Cancer Institute, Amsterdam, The Netherlands

    X
  • Flora E. van Leeuwen,

    Affiliation: Netherlands Cancer Institute, Amsterdam, The Netherlands

    X
  • Jelle Wesseling,

    Affiliation: Netherlands Cancer Institute, Amsterdam, The Netherlands

    X
  • Maggie C. Cheang,

    Affiliation: Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada

    X
  • Karen Gelmon,

    Affiliation: Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada

    X
  • Torsten O. Nielsen,

    Affiliation: Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada

    X
  • Carl Blomqvist,

    Affiliation: Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland

    X
  • Päivi Heikkilä,

    Affiliation: Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland

    X
  • Tuomas Heikkinen,

    Affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

    X
  • Heli Nevanlinna,

    Affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

    X
  • Lars A. Akslen,

    Affiliation: The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway

    X
  • Louis R. Bégin,

    Affiliation: Department of Pathology, McGill University and Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada

    X
  • William D. Foulkes,

    Affiliation: Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada

    X
  • Fergus J. Couch,

    Affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Xianshu Wang,

    Affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Vicky Cafourek,

    Affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Janet E. Olson,

    Affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Laura Baglietto,

    Affiliation: Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia

    X
  • Graham G. Giles,

    Affiliation: Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia

    X
  • Gianluca Severi,

    Affiliation: Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia

    X
  • Catriona A. McLean,

    Affiliation: The Alfred Hospital, Melbourne, Australia

    X
  • Melissa C. Southey,

    Affiliation: Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia

    X
  • Emad Rakha,

    Affiliation: Departments of Histopathology and Surgery, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Nottingham, United Kingdom

    X
  • Andrew R. Green,

    Affiliation: Departments of Histopathology and Surgery, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Nottingham, United Kingdom

    X
  • Ian O. Ellis,

    Affiliation: Departments of Histopathology and Surgery, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Nottingham, United Kingdom

    X
  • Mark E. Sherman,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

    X
  • Jolanta Lissowska,

    Affiliation: M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland

    X
  • William F. Anderson,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

    X
  • Angela Cox,

    Affiliation: Institute for Cancer Studies, University of Sheffield School of Medicine, Sheffield, United Kingdom

    X
  • Simon S. Cross,

    Affiliation: Academic Unit of Pathology, University of Sheffield School of Medicine, Sheffield, United Kingdom

    X
  • Malcolm W. R. Reed,

    Affiliation: Academic Unit of Surgical Oncology, University of Sheffield School of Medicine, Sheffield, United Kingdom

    X
  • Elena Provenzano,

    Affiliation: Department of Oncology, University of Cambridge, United Kingdom

    X
  • Sarah-Jane Dawson,

    Affiliation: Department of Oncology, University of Cambridge, United Kingdom

    X
  • Alison M. Dunning,

    Affiliations: Department of Oncology, University of Cambridge, United Kingdom, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Manjeet Humphreys,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Douglas F. Easton,

    Affiliations: Department of Oncology, University of Cambridge, United Kingdom, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Montserrat García-Closas,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

    X
  • Carlos Caldas,

    Affiliation: Department of Oncology, University of Cambridge, United Kingdom

    X
  • Paul D. Pharoah mail,

    paul.pharoah@srl.cam.ac.uk

    Affiliations: Department of Oncology, University of Cambridge, United Kingdom, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • David Huntsman

    Affiliation: Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada

    X
  • Published: May 25, 2010
  • DOI: 10.1371/journal.pmed.1000279

About the Authors

Fiona M. Blows, Kristy E. Driver, Elena Provenzano, Sarah-Jane Dawson, Alison M. Dunning, Douglas F. Easton, Carlos Caldas, Paul D. Pharoah
Department of Oncology, University of Cambridge, United Kingdom
Marjanka K. Schmidt, Annegien Broeks, Flora E. van Leeuwen, Jelle Wesseling
Netherlands Cancer Institute, Amsterdam, The Netherlands
Maggie C. Cheang, Karen Gelmon, Torsten O. Nielsen, David Huntsman
Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada
Carl Blomqvist
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Päivi Heikkilä
Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
Tuomas Heikkinen, Heli Nevanlinna
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
Lars A. Akslen
The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
Louis R. Bégin
Department of Pathology, McGill University and Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
William D. Foulkes
Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada
Fergus J. Couch, Xianshu Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America
Vicky Cafourek, Janet E. Olson
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
Laura Baglietto, Graham G. Giles, Gianluca Severi
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Catriona A. McLean
The Alfred Hospital, Melbourne, Australia
Melissa C. Southey
Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Australia
Emad Rakha, Andrew R. Green, Ian O. Ellis
Departments of Histopathology and Surgery, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Nottingham, United Kingdom
Mark E. Sherman, William F. Anderson, Montserrat García-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
Jolanta Lissowska
M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland
Angela Cox
Institute for Cancer Studies, University of Sheffield School of Medicine, Sheffield, United Kingdom
Simon S. Cross
Academic Unit of Pathology, University of Sheffield School of Medicine, Sheffield, United Kingdom
Malcolm W. R. Reed
Academic Unit of Surgical Oncology, University of Sheffield School of Medicine, Sheffield, United Kingdom
Alison M. Dunning, Manjeet Humphreys, Douglas F. Easton, Paul D. Pharoah
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: paul.pharoah@srl.cam.ac.uk

Competing Interests

Research in the Genetic Pathology Evaluation Centre is supported in part by an unrestricted educational grant from sanofi-aventis Canada.

Author Contributions

ICMJE criteria for authorship read and met: FMB KED MKS AB FEvL JW MCC KG TON CB PH TH HN LA LRB WF FJC XW VC JEO LB GGG GS CAM MCS ER ARG IOE MES JL WA AC SSC MWRR EP SJD AMD MKH DFE MGC CC PDP DH. Agree with the manuscript's results and conclusions: FMB KED MKS AB FEvL JW MCC KG TON CB PH TH HN LA LRB WF FJC XW VC JEO LB GGG GS CAM MCS ER ARG IOE MES JL WA AC SSC MWRR EP SJD AMD MKH DFE MGC CC PDP DH. Designed the experiments/the study: TON PH MCS IOE JL AMD MGC CC PDP DH. Analyzed the data: FMB KED PH LRB XW MCS MES WA CC PDP. Collected data/did experiments for the study: FMB KED MKS AB JW MCC TON CB PH TH HN LA LRB WF FJC XW VC LB GGG GS CAM MCS ER ARG MES JL AC SSC EP SJD MKH DFE MGC CC PDP DH. Enrolled patients: FEvL KG FJC JEO LB GGG MCS IOE JL MWRR DFE MGC PDP DH. Wrote the first draft of the paper: FMB KED. Contributed to the writing of the paper: MKS FEvL JW KG TON CB PH TH HN LA WF FJC XW JEO LB GGG GS CAM MCS IOE MES JL WA AC SSC MWRR EP SJD DFE MGC CC PDP. Co-ordinated data collation: FMB KED. Contributed to database building and checking of data: MKS. Enrolled patients are derived from a cohort built by me and others: FEvL. Responsible for clinical data integrity: VC. Assistance with TMA construction and scoring of immunohistochemistry: EP. Responsible for pooling data and data cleaning: MH.