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Research Article

Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review

  • Nadeem Sarwar mail,

    nadeem.sarwar@phpc.cam.ac.uk

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

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  • Thor Aspelund,

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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  • Gudny Eiriksdottir,

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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  • Reeta Gobin,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

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  • Sreenivasa Rao Kondapally Seshasai,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

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  • Nita G. Forouhi,

    Affiliation: MRC Epidemiology Unit, Cambridge, United Kingdom

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  • Gunnar Sigurdsson,

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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  • John Danesh equal contributor,

    equal contributor Contributed equally to this work with: John Danesh, Vilmundur Gudnason

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

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  • Vilmundur Gudnason equal contributor

    equal contributor Contributed equally to this work with: John Danesh, Vilmundur Gudnason

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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  • Published: May 25, 2010
  • DOI: 10.1371/journal.pmed.1000278

About the Authors

Nadeem Sarwar, Reeta Gobin, Sreenivasa Rao Kondapally Seshasai, John Danesh
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Thor Aspelund, Gudny Eiriksdottir, Gunnar Sigurdsson, Vilmundur Gudnason
Icelandic Heart Association, Kopavogur, Iceland
Thor Aspelund, Gudny Eiriksdottir, Gunnar Sigurdsson, Vilmundur Gudnason
University of Iceland, Reykjavik, Iceland
Nita G. Forouhi
MRC Epidemiology Unit, Cambridge, United Kingdom

Corresponding Author

Email: nadeem.sarwar@phpc.cam.ac.uk

Competing Interests

JD has received research funding from the British Heart Foundation, BUPA Foundation, Denka, diaDexus, European Union, Evelyn Trust, GlaxoSmithKline MRC, Merck, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke, Novartis, Pfizer, Roche, Wellcome Trust and UK Biobank. John Danesh is on the Editorial Board of PLoS Medicine.

Author Contributions

ICMJE criteria for authorship read and met: NS TA GE RG SRKS NGF GS JD VG. Agree with the manuscript's results and conclusions: NS TA GE RG SRKS NGF GS JD VG. Designed the experiments/the study: NS JD VG. Analyzed the data: NS TA. Collected data/did experiments for the study: NS GE RG SRKS GS VG. Enrolled patients: GS. Wrote the first draft of the paper: NS JD. Contributed to the writing of the paper: NS NS TA NGF GS JD VG. Responsible for data from the Reykjavik Study, derived variables, endpoints and analysis: TA. Contributed to critical revisions of the text: RG SRKS JD. Critically interpreted the findings and revised versions of the manuscript: NGF.