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Research Article

Early Pandemic Influenza (2009 H1N1) in Ho Chi Minh City, Vietnam: A Clinical Virological and Epidemiological Analysis

  • Tran Tinh Hien equal contributor,

    equal contributor Contributed equally to this work with: Tran Tinh Hien, Maciej F. Boni, Juliet E. Bryant, Tran Thuy Ngan, H. Rogier van Doorn

    Affiliations: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Southeast Asian Infectious Diseases Clinical Research Network (SEAICRN, Jakarta, Indonesia

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  • Maciej F. Boni equal contributor mail,

    equal contributor Contributed equally to this work with: Tran Tinh Hien, Maciej F. Boni, Juliet E. Bryant, Tran Thuy Ngan, H. Rogier van Doorn

    mboni@oucru.org

    Affiliations: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, MRC Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom

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  • Juliet E. Bryant equal contributor,

    equal contributor Contributed equally to this work with: Tran Tinh Hien, Maciej F. Boni, Juliet E. Bryant, Tran Thuy Ngan, H. Rogier van Doorn

    Affiliations: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom

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  • Tran Thuy Ngan equal contributor,

    equal contributor Contributed equally to this work with: Tran Tinh Hien, Maciej F. Boni, Juliet E. Bryant, Tran Thuy Ngan, H. Rogier van Doorn

    Affiliations: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Southeast Asian Infectious Diseases Clinical Research Network (SEAICRN, Jakarta, Indonesia

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  • Marcel Wolbers,

    Affiliations: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom

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  • Tran Dang Nguyen,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Nguyen Thanh Truong,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Nguyen Thi Dung,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Do Quang Ha,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Vo Minh Hien,

    Affiliations: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Tran Tan Thanh,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Le Nguyen Truc Nhu,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Le Thi Tam Uyen,

    Affiliations: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Pham Thi Nhien,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Nguyen Tran Chinh,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Nguyen Van Vinh Chau,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Jeremy Farrar,

    Affiliations: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Southeast Asian Infectious Diseases Clinical Research Network (SEAICRN, Jakarta, Indonesia, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom

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  • H. Rogier van Doorn equal contributor

    equal contributor Contributed equally to this work with: Tran Tinh Hien, Maciej F. Boni, Juliet E. Bryant, Tran Thuy Ngan, H. Rogier van Doorn

    Affiliations: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Southeast Asian Infectious Diseases Clinical Research Network (SEAICRN, Jakarta, Indonesia, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom

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  • Published: May 18, 2010
  • DOI: 10.1371/journal.pmed.1000277

About the Authors

Tran Tinh Hien, Maciej F. Boni, Juliet E. Bryant, Tran Thuy Ngan, Marcel Wolbers, Tran Dang Nguyen, Do Quang Ha, Vo Minh Hien, Tran Tan Thanh, Le Nguyen Truc Nhu, Le Thi Tam Uyen, Jeremy Farrar, H. Rogier van Doorn
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Tran Tinh Hien, Nguyen Thanh Truong, Nguyen Thi Dung, Vo Minh Hien, Le Thi Tam Uyen, Pham Thi Nhien, Nguyen Tran Chinh, Nguyen Van Vinh Chau
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Tran Tinh Hien, Tran Thuy Ngan, Jeremy Farrar, H. Rogier van Doorn
Southeast Asian Infectious Diseases Clinical Research Network (SEAICRN, Jakarta, Indonesia
Maciej F. Boni
MRC Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom
Maciej F. Boni, Juliet E. Bryant, Marcel Wolbers, Jeremy Farrar, H. Rogier van Doorn
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom

Corresponding Author

Email: mboni@oucru.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: TTH MFB JEB TTN MW TDN NTT NTD DQH VMH TTT LNTN LTTU PTN NTC NVVC JF HRvD. Agree with the manuscript's results and conclusions: TTH MFB JEB TTN MW TDN NTT NTD DQH VMH TTT LNTN LTTU PTN NTC NVVC JF HRvD. Designed the experiments/the study: TTH TTN DQH LTTU PTN NVVC JF HRvD. Analyzed the data: TTH MFB JEB MW DQH TTT JF HRvD. Collected data/did experiments for the study: TTH JEB TTN TDN NTT NTD DQH VMH TTT LNTN LTTU PTN HRvD. Enrolled patients: TTH NTT NTD JF. MFB, HRvD, and JEB co-wrote the first draft of the paper, and wrote most of the paper. Contributed to the writing of the paper: TTH MFB JEB TTN MW DQH VMH PTN NTC NVVC JF HRvD. MFB did the epidemiological analysis. MFB and MW did the statistical analysis. TDN collected and analyzed epidemiological data.