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Research Article

Effectiveness of Non-nucleoside Reverse-Transcriptase Inhibitor-Based Antiretroviral Therapy in Women Previously Exposed to a Single Intrapartum Dose of Nevirapine: A Multi-country, Prospective Cohort Study

  • Jeffrey S. A. Stringer mail,

    stringer@cidrz.org

    Affiliation: University of Alabama at Birmingham Centre for Infectious Disease Research in Zambia, Lusaka, Zambia

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  • Michelle S. McConnell,

    Affiliations: Thailand Ministry of Public Health—US Centers for Disease Control and Prevention (CDC) Collaboration, Nonthaburi, Thailand, Global AIDS Program, CDC, Atlanta, Georgia, United States of America

    X
  • James Kiarie,

    Affiliations: Kenyatta National Hospital, Nairobi, Kenya, University of Nairobi, Nairobi, Kenya

    X
  • Omotayo Bolu,

    Affiliation: Global AIDS Program, CDC, Atlanta, Georgia, United States of America

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  • Thanomsak Anekthananon,

    Affiliation: Siriraj Hospital, Mahidol University, Bangkok, Thailand

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  • Tavatchai Jariyasethpong,

    Affiliation: Rajavithi Hospital, Bangkok, Thailand

    X
  • Dara Potter,

    Affiliations: University of Alabama at Birmingham Centre for Infectious Disease Research in Zambia, Lusaka, Zambia, Global AIDS Program, CDC-Zambia, Lusaka, Zambia

    X
  • Winnie Mutsotso,

    Affiliation: Global AIDS Program, CDC-Kenya, Nairobi, Kenya

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  • Craig B. Borkowf,

    Affiliation: Division of HIV/AIDS Prevention, CDC, Atlanta, Georgia, United States of America

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  • Dorothy Mbori-Ngacha,

    Affiliations: University of Nairobi, Nairobi, Kenya, Global AIDS Program, CDC-Kenya, Nairobi, Kenya

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  • Peter Muiruri,

    Affiliation: Kenyatta National Hospital, Nairobi, Kenya

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  • John Odero Ong'ech,

    Affiliations: Kenyatta National Hospital, Nairobi, Kenya, University of Nairobi, Nairobi, Kenya

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  • Isaac Zulu,

    Affiliations: Global AIDS Program, CDC-Zambia, Lusaka, Zambia, University Teaching Hospital, Lusaka, Zambia

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  • Lungowe Njobvu,

    Affiliation: University of Alabama at Birmingham Centre for Infectious Disease Research in Zambia, Lusaka, Zambia

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  • Bongkoch Jetsawang,

    Affiliation: Thailand Ministry of Public Health—US Centers for Disease Control and Prevention (CDC) Collaboration, Nonthaburi, Thailand

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  • Sonal Pathak,

    Affiliations: Division of HIV/AIDS Prevention, CDC, Atlanta, Georgia, United States of America, Northrup-Grumman Corporation, Atlanta, Georgia, United States of America

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  • Marc Bulterys,

    Affiliation: Global AIDS Program, CDC-Zambia, Lusaka, Zambia

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  • Nathan Shaffer,

    Affiliation: Global AIDS Program, CDC, Atlanta, Georgia, United States of America

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  • Paul J. Weidle

    Affiliation: Division of HIV/AIDS Prevention, CDC, Atlanta, Georgia, United States of America

    X
  • Published: February 16, 2010
  • DOI: 10.1371/journal.pmed.1000233
  • Featured in PLOS Collections

About the Authors

Jeffrey S. A. Stringer, Dara Potter, Lungowe Njobvu
University of Alabama at Birmingham Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
Michelle S. McConnell, Bongkoch Jetsawang
Thailand Ministry of Public Health—US Centers for Disease Control and Prevention (CDC) Collaboration, Nonthaburi, Thailand
Michelle S. McConnell, Omotayo Bolu, Nathan Shaffer
Global AIDS Program, CDC, Atlanta, Georgia, United States of America
James Kiarie, Peter Muiruri, John Odero Ong'ech
Kenyatta National Hospital, Nairobi, Kenya
James Kiarie, Dorothy Mbori-Ngacha, John Odero Ong'ech
University of Nairobi, Nairobi, Kenya
Thanomsak Anekthananon
Siriraj Hospital, Mahidol University, Bangkok, Thailand
Tavatchai Jariyasethpong
Rajavithi Hospital, Bangkok, Thailand
Dara Potter, Isaac Zulu, Marc Bulterys
Global AIDS Program, CDC-Zambia, Lusaka, Zambia
Winnie Mutsotso, Dorothy Mbori-Ngacha
Global AIDS Program, CDC-Kenya, Nairobi, Kenya
Craig B. Borkowf, Sonal Pathak, Paul J. Weidle
Division of HIV/AIDS Prevention, CDC, Atlanta, Georgia, United States of America
Isaac Zulu
University Teaching Hospital, Lusaka, Zambia
Sonal Pathak
Northrup-Grumman Corporation, Atlanta, Georgia, United States of America

Corresponding Author

Email: stringer@cidrz.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: JSAS MSM JNK OB TA TJ DP WM CBB DMN PM JOO IZ LN BJ SP MB NS PW. Agree with the manuscript's results and conclusions: JSAS MSM JNK OB TA TJ DP WM CBB DMN PM JOO IZ LN BJ SP MB NS PW. Designed the experiments/the study: JSAS MSM JNK TA TJ DMN JOO IZ BJ NS PW. Analyzed the data: JSAS JNK OB TJ CBB JOO SP NS PW. Collected data/did experiments for the study: MSM JNK TA TJ DP PM JOO LN. Enrolled patients: MSM JNK TA TJ DP PM JOO LN BJ. Wrote the first draft of the paper: JSAS TJ CBB PW. Contributed to the writing of the paper: JSAS MSM JNK OB TA TJ DP WM CBB DMN PM JOO IZ MB NS PW. Supervised the study: JSAS. Developed the protocol, and responsible for study implementation and data collection and integrity at two sites: MSM. Participated in the coordination of the study, and helped to provide technical input and support: OB. Provided administrative supervision and support during study implementation as the Project Officer in charge of the program; reviewed and contributed to writing of the study protocol for Kenya: WM. Contributed to discussions of data and results: IZ. Responsible for data integrity: LN. Responsible for data integrity and quality: SP. Provided leadership in development of the protocol, IRB clearance, securing funding, organizing collaborator meetings, and communications: NS.