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Research Article

A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example

  • Tjeerd-Pieter van Staa mail,

    Tjeerd.vanstaa@GPRD.com

    Affiliations: General Practice Research Database, London, United Kingdom, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

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  • Hubert G. Leufkens,

    Affiliation: Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

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  • Bill Zhang,

    Affiliation: General Practice Research Database, London, United Kingdom

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  • Liam Smeeth

    Affiliation: London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Published: December 08, 2009
  • DOI: 10.1371/journal.pmed.1000194

About the Authors

Tjeerd-Pieter van Staa, Bill Zhang
General Practice Research Database, London, United Kingdom
Tjeerd-Pieter van Staa, Hubert G. Leufkens
Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Liam Smeeth
London School of Hygiene & Tropical Medicine, London, United Kingdom

Corresponding Author

Email: Tjeerd.vanstaa@GPRD.com

Competing Interests

TPvS and BZ: The General Practice Research Database receives funding from the Medicines and Healthcare products Regulatory Agency, pharmaceutical companies, universities, and contract research organizations. TPvS and HGML: The Utrecht Institute for Pharmaceutical Sciences at Utrecht University has received unrestricted funding for pharmacoepidemiological research from GlaxoSmithKline, Novo Nordisk, the private-public funded Top Institute Pharma (http://www.tipharma.nl; includes co-funding from universities, government, and industry), the Dutch Medicines Evaluation Board, and the Dutch Ministry of Health. LS is funded by a Wellcome Trust Senior Research Fellowship in Clinical Science.

Author Contributions

ICMJE criteria for authorship read and met: TPVS HGL BZ LS. Agree with the manuscript's results and conclusions: TPVS HGL BZ LS. Designed the experiments/the study: TPVS HGL BZ LS. Analyzed the data: TPVS BZ. Wrote the first draft of the paper: TPVS. Contributed to the writing of the paper: TPVS HGL BZ LS.